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Nano-magnetite supported N-heterocyclic carbene-gold complex with pendant ferrocenyl group as a multi-modal anti-breast cancer agent

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Abstract

A novel nano-magnetite supported N-heterocyclic carbene-gold complex with pendant ferrocenyl group has been prepared by using a multi-step procedure. The complex displayed considerable anticancer activity against the MCF-7 breast cancer cell line with IC50 = 32.38 ± 0.31 µg/mL as compared with standard drug 5-fluorouracil (IC50 = 25.29 ± 0.11 µg/mL) in the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay. The in-ovo anti-angiogenic activity of the complex using chicken chorioallantoic membrane (CAM) assay showed significant decrease in secondary blood vessels indicating that it is an efficient angiogenesis inhibitor. The magnetic hyperthermia studies of the complex revealed a significant specific absorption rate (SAR) value of 246.974 W g−1 with therapeutic temperature of 46.8°C.

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Supporting information contains the description of the methods, experimental methods and materials used in this work as well as characterization techniques and experimental tables.

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Acknowledgements

We gratefully acknowledge Indian Institute of Sciences (IISc), Bangalore, and Sophisticated Analytical Instrumental Facility, Indian Institute of Technology, Bombay (IITB), Indian Institute of Technology, Madras (IITM), Northern East Hill University, Shillong (NEHU), and Central Facility Center (CFC), Shivaji University, Kolhapur, for providing spectral facilities and SARTHI for providing Research Fellowship (CSMNRF).

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No funds, grants, or other support was received.

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Authors and Affiliations

  1. Department of Chemistry, Shivaji University, Kolhapur, 416004, Maharashtra, India

    Pradnya V. Patil, Prakash A. Bansode, Shivanand P. Gajare, Ajit H. Deshmukh, Dattaprasad M. Pore & Gajanan S. Rashinkar

  2. Center for Interdisciplinary Research, D.Y Patil Education Society Deemed University, Kolhapur, 416006, Maharashtra, India

    Arpita P. Tiwari & Vishwajeet M. Khot

  3. Department of Chemistry, Sangola College, Sangola, 413307, Maharashtra, India

    Prakash A. Bansode

  4. Dr. Shivajirao, Kadam Collage of Pharmacy, Kasbe Digraj, Sangli, 416146, Maharashtra, India

    Sandeep B. Patil

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  1. Pradnya V. Patil
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  3. Shivanand P. Gajare
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Contributions

All authors contributed to the study’s conception and design. Material preparation, data collection and analysis were performed by Miss P.V. Patil. The first draft of the manuscript was written by Prof. G. S. Rashinkar and Prof. Dr. D. M. Pore and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Gajanan S. Rashinkar.

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Patil, P.V., Bansode, P.A., Gajare, S.P. et al. Nano-magnetite supported N-heterocyclic carbene-gold complex with pendant ferrocenyl group as a multi-modal anti-breast cancer agent. Res Chem Intermed 49, 5141–5161 (2023). https://doi.org/10.1007/s11164-023-05088-2

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