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The Impact of Post-Processing Temperature on PLGA Microparticle Properties

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Abstract

Purpose

Biodegradable poly(lactide-co-glycolide) (PLGA) microparticles loaded with either risperidone or naltrexone were prepared from an emulsification homogenization process. The objective of this study was to determine the impact the post-treatment temperature has on the properties and subsequent performance of the microparticles.

Methods

The post-treatment temperature of an ethanolic solution was characterized from 10 ~ 35ºC for the naltrexone and risperidone micropartilces.

Results

The wash temperature resulted in a typical triphasic in vitro release pattern at low wash temperatures or a biphasic pattern consisting of an elevated release rate at higher post-treatment temperatures. The post-treatment temperature largely influences the particle morphology, residual solvent levels, glass transition temperature, and drug loading and is molecule dependent, whereby these characteristics subsequently influence the drug release rate.

Conclusion

The study highlights the importance of both the post-treatment process and control during manufacturing to obtain a formulation within the desired product profile.

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Data Availability

The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.

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Acknowledgements

This study was supported by UH3 DA048774 from the National Institute on Drug Abuse (NIDA) and the Showalter Research Trust Fund.

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Authors and Affiliations

  1. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA

    Andrew Otte, Bong Kwan Soh & Kinam Park

  2. Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, 47907, USA

    Andrew Otte & Kinam Park

  3. Chong Kun Dang Pharmaceuticals Inc, Seoul, Republic of Korea

    Bong Kwan Soh

  4. Akina, Inc, West Lafayette, IN, 47906, USA

    Kinam Park

Authors
  1. Andrew Otte
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  2. Bong Kwan Soh
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Correspondence to Andrew Otte.

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Otte, A., Soh, B.K. & Park, K. The Impact of Post-Processing Temperature on PLGA Microparticle Properties. Pharm Res 40, 2677–2685 (2023). https://doi.org/10.1007/s11095-023-03568-z

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  • DOI: https://doi.org/10.1007/s11095-023-03568-z

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