Pharmacokinetics and bioavailability of the new drug protecor upon peroral administration in rabbits and beagle dogs

Abstract

A new high-performance liquid chromatographic method with ultraviolet detection has been used to determine the levels of the new cardiotropic drug protecor in the blood of animals (chincilla rabbits, 2.2 ± 0.2 kg; and beagle dogs, 10 ± 0.5 kg). The parameters of protecor pharmacokinetics and bioavailability upon peroral administration of protecor tablets have been determined. Rabbits showed effective absorption of the drug uupon peroral administration in a single dose (100 mg/kg) with a peak concentration in the plasma (C _max= 41 µg/mL) reached within T _max= 3 h followed by rapid removal of the drug from the organism with a half-elimination time T _/12β=1.71 h. Peroral administration of protecor in a single dose (50 mg/kg) in beagle dogs was characterized by C _max= 34.6 µg/mL, T _max = 3 h, and T _/12β=0.75 h. The bioavailability of protecor upon peroral administration was estimated at 90% (rabbits) and 80.7% (beagle dogs).