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Pediatric primary central nervous system tumors registry in Thailand under National Health Security Office schemes

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Abstract

Background

Few epidemiological studies of pediatric central nervous system (CNS) tumors have been performed using data from Southeast Asian national registries. Therefore, we aimed to examine data on CNS tumors from the first national childhood CNS tumor registry in Thailand.

Methods

Newly diagnosed children with benign and malignant primary CNS tumors from 20 nationwide hospitals were included. Two eras in the Thai registry were studied to compare national protocol effectiveness, including 2003–2005 (before establishment of a pediatric CNS tumor protocol) and 2011–2012 (post-establishment).

Results

The first study period had 300 patients with an incidence of 7.5/1,000,000 person-years and the second had 168 patients with an incidence of 13.24/1,000,000 person-years. The three most common tumors were gliomas, medulloblastoma/primitive neuroectodermal tumor (PNET), and germ cell tumors. The most common tumor site was the cerebellum, followed by the brainstem and pineal region. Five- and 10-year overall survival (OS) rates were 46.62% (95% confidence interval [CI] 40.85–52.18) and 41.78% (95% CI 36.11–47.34), respectively, for the first period. The second period had a 5-year OS of 64.75% (95% CI 56.70–71.68). OS rates for gliomas, germ cell tumors, medulloblastoma/PNET, and ependymomas were better in the second period than in the first period.

Conclusions

The incidence of primary childhood CNS tumors in our study is lower compared with other reports. Improvement of OS in the second study period might be because of establishment of the Thai Pediatric Oncology Group, and national protocols for childhood CNS tumors.

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Acknowledgements

This study was financial supported by Ramathibodi Foundation, Children Cancer Fund under The Patronage of HRH Princess Soamsawali and My Child Matters Grant Award UICC awarded to Dr. Suradej Hongeng, and National health security office of Thailand. We thank Ellen Knapp, PhD, from Edanz Group (https://www.edanzediting.com/ac) for editing a draft of this manuscript.

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Authors and Affiliations

  1. Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand

    Bunchoo Pongtanakul, Kleebsabai Sanpakit & Sommaphun Tabjareon

  2. Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand

    Nongnuch Sirachainan & Suradej Hongeng

  3. Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani, 12120, Thailand

    Pacharapan Surapolchai

  4. Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand

    Pimlak Charoenkwan & Worawut Choeyprasert

  5. Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

    Patcharee Komwilaisak

  6. Department of Pediatrics, Khon Kaen Hospital, Khon Kaen, 40000, Thailand

    Su-on Chainansamit

  7. Department of Pediatrics, Nakhon Ratchasima Hospital, Nakhon Ratchasima, 30000, Thailand

    Nittaya Witsanuyothin

  8. Department of Pediatrics, Sappasitthiprasong Hospital, Ubon Ratchathani, 34000, Thailand

    Yu**da Lertrakul

  9. Department of Pediatrics, Phramongkutklao Hospital, Bangkok, 10400, Thailand

    Piya Rujkijyanont

  10. Department of Pediatrics, Queen Sirikit National Institute of Child Health, Bangkok, 10400, Thailand

    Somjai Kanjanapongkul

  11. Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, 10330, Thailand

    Darintr Sosothikul

  12. Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand

    Thirachit Chotsampancharoen

  13. Department of Pediatrics, Buddhachinaraj Phitsanulok Hospital, Phitsanulok, 65000, Thailand

    Somporn Wangruangsathit

  14. Ramathibodi Comprehensive Cancer Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand

    Nintita Sripaiboonkij Thokanit

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  1. Bunchoo Pongtanakul
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  2. Nongnuch Sirachainan
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Correspondence to Suradej Hongeng.

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Pongtanakul, B., Sirachainan, N., Surapolchai, P. et al. Pediatric primary central nervous system tumors registry in Thailand under National Health Security Office schemes. J Neurooncol 149, 141–151 (2020). https://doi.org/10.1007/s11060-020-03582-w

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  • DOI: https://doi.org/10.1007/s11060-020-03582-w

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