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Drug Encapsulation: Review of Niosomes for Promoting Antimicrobial Activity

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Abstract

Nanotechnology has been used for drug encapsulation with the development of more effective and less toxic nanomedicines. Some currently used antimicrobials present problems with their physicochemical characteristics and the emergence of resistant microorganisms. Thus, encapsulating these drugs in nanocarriers would be a promising alternative to overcome these problems. This systematic review aims to evaluate the development of niosomes for encapsulation of antimicrobials, highlighting studies with in vitro and in vivo research. A search was performed in the MEDLINE/PubMed and Web of Science databases from 2011 to May 2021 with an exclusion, eligibility, and classification criteria. Twenty articles were selected to write this review. It was observed that the niosomes produced presented differences in physicochemical characteristics according to the non-ionic surfactant used. The evaluation of cell and animal assays revealed that niosomes presented a significantly higher antimicrobial efficacy when compared to the free drug. A reduction in toxicity could also be observed. Thus, the development of niosome-based nanomedicines has progressed over the years and is a promising strategy to increase therapeutic efficacy and reduce drug toxicity.

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Acknowledgements

The authors are grateful to Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Rede NanoSaude and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for their support.

Funding

This paper was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Brazilian agency; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)— Cientista do Nosso Estado (CNE) [grant number: E-26/201.077/2021]; Apoio aos Programas e Cursos de Pós-Graduação Stricto Sensu do Estado do Rio de Janeiro 2020 [grant number: E-26/210.136/2021]; Rede NanoSaude [grant number: E-26/010.000981/2019]; and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) - Bolsa Produtividade em Pesquisa PQ [grant number: 309522/2020-2].

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Authors and Affiliations

  1. Galenic Development Laboratory, University Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

    Tatielle do Nascimento, Denise de Abreu Garófalo, Mariana Sato de Souza Bustamante Monteiro, Ana Paula dos Santos Matos & Eduardo Ricci-Júnior

  2. Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro, Brazil

    Ralph Santos-Oliveira

  3. Zona Oeste State University, Laboratory of Nanoradiopharmacy and Radiopharmaceuticals, Rio de Janeiro, Brazil

    Ralph Santos-Oliveira

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  1. Tatielle do Nascimento
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All authors contributed to the study conception and design. Tatielle do Nascimento: conceptualization, methodology, formal analysis, investigation, data curation, writing (review and editing), visualization, and project administration. Denise de Abreu Garófalo: writing (review and editing), and visualization. Mariana Sato de Souza Bustamante Monteiro: writing (review and editing), and visualization. Ralph Santos-Oliveira: writing (review and editing), and visualization. Ana Paula dos Santos Matos: conceptualization, methodology, writing (review and editing), visualization, supervision, and project administration. Eduardo Ricci-Júnior: conceptualization, methodology, writing (review and editing), visualization, supervision, and project administration.

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do Nascimento, T., de Abreu Garófalo, D., de Souza Bustamante Monteiro, M.S. et al. Drug Encapsulation: Review of Niosomes for Promoting Antimicrobial Activity. J Nanopart Res 24, 262 (2022). https://doi.org/10.1007/s11051-022-05637-7

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