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A comparative phylogenomic analysis of peste des petits ruminants virus isolated from wild and unusual hosts

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Abstract

Peste des petits ruminants virus (PPRV) infects a wide range of domestic and wild ruminants, and occasionally unusual hosts such as camel, cattle and pig. Given their broad host-spectrum and disease endemicity in several develo** countries, it is imperative to elucidate the viral evolutionary insights for their dynamic pathobiology and differential host-selection. For this purpose, a dataset of all available (n = 37) PPRV sequences originating from wild and unusual hosts was composed and in silico analysed. Compared to domestic small ruminant strains of same geographical region, phylogenomic and residue analysis of PPRV sequences originating from wild and unusual hosts revealed a close relationship between strains. A lack of obvious difference among the studied sequences and deduced residues suggests that these are the host factors that may play a role in their susceptibility to PPRV infection, immune response, pathogenesis, excretion patterns and potential clinical signs or resistance to clinical disease. Summarizing together, the comparative analysis enhances our understanding towards molecular epidemiology of the PPRV in wild and unusual hosts for appropriate intervention strategies particularly at livestock-wildlife interface.

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Authors and Affiliations

  1. University of Veterinary and Animal Sciences, Lahore, 54600, Pakistan

    Aziz-ul- Rahman & Muhammad Zubair Shabbir

  2. Division of Biomedical and Life Sciences, Lancaster University, Lancaster, LA1 4YG, UK

    Muhammad Munir

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  1. Aziz-ul- Rahman
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  2. Muhammad Munir
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  3. Muhammad Zubair Shabbir
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Contributions

AR, MZS apprehended the idea: AR, MM, MZS conceived and designed the work; AR, MZS did data analysis; AR, MM, MZS edited final draft.

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Correspondence to Aziz-ul- Rahman.

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Rahman, Au., Munir, M. & Shabbir, M.Z. A comparative phylogenomic analysis of peste des petits ruminants virus isolated from wild and unusual hosts. Mol Biol Rep 46, 5587–5593 (2019). https://doi.org/10.1007/s11033-019-04973-7

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  • DOI: https://doi.org/10.1007/s11033-019-04973-7

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