Abstract
A series of novel and diverse diaryl[d,f][1,3]diazepines were designed and synthesized to expand the pharmaceutical utility of the [6,7]bicyclic molecular skeletons. The facile synthesis involved two key steps: a one-pot Suzuki coupling to construct the bi-aryl intermediates from corresponding halides, and a ring closure by direct condensation with carboxylic acids.
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Yan, L., Che, X., Bai, X. et al. Syntheses of novel diaryl[d,f ][1,3]diazepines via one-pot Suzuki coupling followed by direct ring closure with carboxylic acids. Mol Divers 16, 489–501 (2012). https://doi.org/10.1007/s11030-012-9382-1
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DOI: https://doi.org/10.1007/s11030-012-9382-1