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Production of 61Cu by the natZn(p,α) reaction: improved separation and specific activity determination by titration with three chelators

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Abstract

The cyclotron-based production of positron-emitting 61Cu using the (p,α) reaction at 11.7 MeV was investigated starting from natural-zinc (natZn) and enriched 64Zn-foil targets, as well as its subsequent purification. For natZn, a combination of three resins were assessed to separate 61Cu from contaminating 66,67,68Ga and natZn. The specific activity of the purified 61Cu determined using ICP-MS analysis ranged from 143.3 ± 14.3(SD) to 506.2 ± 50.6 MBq/µg while the titration method using p-SCN-Bn-DOTA, p-SCN-Bn-NOTA and diamsar gave variable results (4.7 ± 0.2–412.5 ± 15.3 MBq/µg), with diamsar lying closest to the ICP-MS values. Results suggest that the p-SCN-Bn-DOTA and p-SCN-Bn-NOTA titration methods are significantly affected by the presence of trace-metal contaminants.

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Acknowledgments

The authors express their thanks to the Medical Technology and Physics radiochemists and engineering staff for providing scientific materials and other support.

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Author notes

  1. Ali H. Asad

    Present address: Radiopharmaceutical Production & Development (RAPID) Laboratory, Medical Technology and Physics, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Perth, WA, 6009, Australia

Authors and Affiliations

  1. Radiopharmaceutical Production & Development (RAPID) Laboratory, Medical Technology and Physics, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Perth, WA, 6009, Australia

    Laurence M. Morandeau, Sun Chan, Charmaine M. Jeffery & Roger I. Price

  2. Department of Imaging & Applied Physics, Curtin University, Perth, WA, 6845, Australia

    Ali H. Asad

  3. Medical Isotope Research and Production Program, Collider-Accelerator Department, Brookhaven National Laboratory, Upton, NY, 11973, USA

    Suzanne V. Smith

  4. School of Physics, University of Western Australia, Nedlands, WA, 6009, Australia

    Roger I. Price

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  1. Ali H. Asad
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Correspondence to Ali H. Asad.

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Asad, A.H., Smith, S.V., Morandeau, L.M. et al. Production of 61Cu by the natZn(p,α) reaction: improved separation and specific activity determination by titration with three chelators. J Radioanal Nucl Chem 307, 899–906 (2016). https://doi.org/10.1007/s10967-015-4412-y

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  • DOI: https://doi.org/10.1007/s10967-015-4412-y

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