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Comparison of estimated human effective dose of 67Ga- and 99mTc-labeled bombesin based on distribution data in mice

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Abstract

This study describes the preparation, biodistribution and absorbed dose prediction of 67Ga and 99mTc labeled bombesin (BBN) in human organs, after injection in mice determined via medical internal radiation dose. We estimated that a 185-MBq injection of 67Ga-BBN into the humans would result in an estimated effective absorbed dose of 2.50 mSv whereas this value for 99mTc-BBN is 1.33 mSv in the whole body. These results suggest that injection of 67Ga-BBN would result 2 times higher absorbed dose compare to 99mTc-BBN.

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Acknowledgments

The authors should thank to Prof. Micheal G. Stabin for his supportive comments about this paper. This work was supported by Radiation Application research School of Nuclear Science & Technology Research Institute (NSTRI).

Conflict of interests

The authors declare that they have no conflict of interest.

Financial support

This work was supported by Radiation Application Research School of Nuclear Science & Technology Research Institute (NSTRI).

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Authors and Affiliations

  1. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), P.O.Box:11365-3486, Tehran, Iran

    Saeed Shanehsazzadeh & Mostafa Erfani

  2. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Afsaneh Lahooti

  3. Central Iran Research Complex (Yazd), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

    Seyed Pezhman Shirmardi

  4. Nuclear Fuel Cycle Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

    Seyed Pezhman Shirmardi

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  1. Saeed Shanehsazzadeh
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Correspondence to Saeed Shanehsazzadeh.

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Shanehsazzadeh, S., Lahooti, A., Shirmardi, S.P. et al. Comparison of estimated human effective dose of 67Ga- and 99mTc-labeled bombesin based on distribution data in mice. J Radioanal Nucl Chem 305, 513–520 (2015). https://doi.org/10.1007/s10967-015-3995-7

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