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Preparation of 99mTc-MIBI complex under ultrasound irradiation

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Abstract

The (37MBq) 99mTc-MIBI complex samples were prepared due to ultrasound irradiation technique or boiled water bath method as a standard method. The qualitative and quantitative studies have been performed. The accumulation of 99mTc-MIBI complexes prepared by two above mentioned modalities were approximately 3 ± 0.1 % in the rats’ heart. The ultrasound irradiation technique is recommended to prepared 99mTc-MIBI complex in efficiently amount. Our approach can potentially reduce medical risk to the patient by avoiding any delay in acute therapy particularly for myocardial infarction patients.

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Acknowledgments

This study is part of pharm-D thesis of Hossein Hassanpur and special thanks to Ahvaz Jundishapur University of Medical Sciences for the financial support and also to Radioisotope Division of Atomic Energy Organization of Iran for providing the freeze-dried MIBI kits and 99Mo/99mTc generator.

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Authors and Affiliations

  1. School of Pharmacy of Ahvaz Jundishapur of Medical Sciences, 6135733184, Ahvaz, Iran

    Alireza Doroudi, Hossein Hassan Pour, Saeed Rezaee, Mohammad Javad Khodayar & Hamidreza Samaee

  2. Department of Nuclear Medicine of Golestan Hospital, Ahvaz Jundishapur of Medical Sciences, Ahvaz, Iran

    Seyyed Mostafa Saadati, Faramarz Ahmadi & Behrouz Etesami

  3. Nuclear Science Research School, Nuclear Science and Technology Research Institute (NSTRI), Atomic Energy Organization of Iran (AEOI), 6135733184, Tehran, Iran

    Mostafa Erfani

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  1. Alireza Doroudi
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  2. Seyyed Mostafa Saadati
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  3. Hossein Hassan Pour
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  9. Behrouz Etesami
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Correspondence to Alireza Doroudi.

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Doroudi, A., Saadati, S.M., Pour, H.H. et al. Preparation of 99mTc-MIBI complex under ultrasound irradiation. J Radioanal Nucl Chem 298, 1185–1190 (2013). https://doi.org/10.1007/s10967-013-2559-y

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  • DOI: https://doi.org/10.1007/s10967-013-2559-y

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