Abstract
A kind of novel three-dimensionally ordered macroporous molecularly imprinted microspheres (3DMIMs) had been developed for selective recognition and separation of quinine based on the combination of colloidal crystal templating method and molecular imprinting technique. The 3DMIMs were derived from the spherical silica colloidal crystal involving a four-step templating process including infiltration of imprinted precursors, sealing of polyethylene glycol, initiation polymerization, as well as final removal of the colloidal crystal and imprinting template. The resulted 3DMIMs consisted of a three-dimensional, highly ordered and interconnected macroporous arrays with nanoscale thickness of polymer wall, in which numerous imprinted cavities were obtained. The kinetic and isothermal adsorption behavior of the 3DMIMs were investigated in detail. The results showed the 3DMIMs had a rapider mass transfer process, higher adsorption capacities and recognition specificity toward quinine compared with the traditional bulk imprinted polymers. In addition, the 3DMIMs exhibited obvious high permeability and low backpressure at high flow rate as column packing. Extraction experiments showed that the 3DMIMs could effectively separate quinine and its diastereoisomer, quinidine, directly from crude cinchona bark extract with a satisfactory selectivity and elution recovery.
Similar content being viewed by others
References
Xu LH, Pan MF, Fang GZ, Wang S (2019) Sensor Actuat B-Chem 286:321–327
Roya FT, Reza M, Mohammad AK, Lee DW, Sajad P (2020) J Polym Res 27:35
Sa**i T, Gigimol MG, Mathew B (2019) J Polym Res 26:88
Gao FX, Ma XT, He XW, Li WY, Zhang YK (2013) Colloid Surf A-Physicochem Eng Asp 433:191–199
Wang SS, Ye J, Bie ZJ, Liu Z (2014) Chem Sci 5:1135–1140
He PY, Zhu HJ, Ma Y, Liu N, Niu XH, Wei MB, Pan JM (2019) Chem Eng J 367:55–63
Yousefzadeha A, Hassanzadeh J, Mousavia SMJ, Yousefzadehc M (2019) Sensor Actuat B-Chem 286:154–162
Xu DD, Li SQ, Pan T, He JF, Wu QZ (2018) Chem Lett 47:686–689
Pan DD, Xun MY, Lan HZ, Li JL, Wu Z, Guo YX (2019) Anal Bioanal Chem 411:7737–7745
Zhang YN, Huang SM, Qian CT, Wu QZ, He JF (2016) J Appl Polym Sci 43191:1–8
Zhang YN, Huang SM, Xu DD, Chen JC, Wu QZ, He JF (2017) Int J Polym Mater 66:82–88
Li SQ, Xu DD, Pan T, Wu QZ, He JF (2018) Colloid Polym Sci 296:1267–1271
Kadhem AJ, **ang ST, Nagel S, Lin CH, Cortalezzi MFD (2018) Polymers 10:349
Qiu XZ, Chen WM, Luo YL, Wang YL, Wang YL, Guo HS (2020) Anal Chim Acta 1093:142–149
Gachelin G, Garner P, Ferroni E, Trohler U, Chalmers I (2017) J Roy Soc Med 110:31–40
Chou KS, Chen CC (2008) Ceram Int 34:1623–1627
Vlakh EG, Maksimova EF, Tennikova TB (2013) Polym Sci Ser B 55:55–62
Cheng C, Yang TZ, He YH, Yang L, Wang LX (2013) Mater Lett 109:257–260
He JF, Zhu QH, Deng QY (2007) Spectrochim Acta A 67:1297–1305
Peng HL, Wang SQ, Zhang Z, **ong H, Li JH, Chen LX, Li YB (2012) J Agric Food Chem 60:1921–1928
Zhao YJ, Zhao XW, Hu J, Li J, Xu WY, Gu ZZ (2009) Angew Chem Int Ed 48:7350–7352
Mohanty P, Fei YW, Landskron K (2009) J Am Chem Soc 131:9638–9639
Sun BB, Guo F, Guo HF, Wang DF, Li R (2014) Chin J Guangzhou Chem Ind 42:119–121
Li HN, Dai HX, He H (2009) J Sci Conf Proc 1:186–189
Peng MJ, **ang HY, Hu X, Shi SY, Chen XQ (2016) J Chromatogr A 1474:8–13
Castro López MDM, Pérez MCC, García MSD, Vilarino JML, González Rodríguez MV, Losada LFB (2012) Anal Chim Acta 721:68–78
Tan IAW, Ahmad AL, Hameed BH (2009) J Hazard Mater 164:473–482
Acknowledgments
This work was financially supported by the National Natural Science Foundation of
China (No. 81303199) and the Guangdong Province Natural Science Foundation of
China (No.2017A030313675).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors have declared no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Lin, Y., Liu, Y., Li, S. et al. Template-directed preparation of three-dimensionally ordered macroporous molecularly imprinted microspheres for selective recognition and separation of quinine from cinchona extract. J Polym Res 28, 179 (2021). https://doi.org/10.1007/s10965-021-02533-x
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s10965-021-02533-x