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Synthesis of Copper Oxide Nanoparticles Coated on 3-Glycidoxypropyltrimethoxysilane /Folic Acid/ Hyaluronic Acid, and Its Application as Drug Delivery System: Kinetics, Equilibrium, and Thermodynamic Studies

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Abstract

In this work, copper oxide nanoparticles (CuO NPs) were successfully synthesized by a simple chemical process. After conjugation of 3-glycidoxypropyltrimethoxysilane (GPTMS), the surfaces of CuO NPs@ GPTMS were functionalized with hyaluronic acid (HA) and folic acid (FA) for the formation of CuO NPs@ GPTMS@HA-FA. The samples were characterized by field emission scanning electron microscopy (FE-SEM) and X-ray diffraction (XRD). Surface modification of CuO NPs with Fourier-transform infrared (FT-IR), thermo-gravimetric analysis (TGA), and CHN analysis was proven. Imatinib mesylate (IM) adsorption was studied under various conditions. The maximum sorption capacity was achieved at pH = 6, a contact time of 30 min, an adsorbent dosage of 0.01 g, and a temperature of 298 K. The evaluation of kinetic and isotherm models showed that the pseudo-second-order and Langmuir models were selected as the best fitting model to describe the adsorption method. In vitro release investigations of IM from the CuO NPs@ GPTMS@HA-FA were performed in stimulated human blood fluid (pH = 7.4) and cancer fluid (pH = 5.6) at 37 °C. Release of − 47.10% of IM from CuO NPs@ GPTMS@HA-FA was observed within a period of 6 h at pH = 5.6. The investigation shows that IM, an anticancer drug can be successfully entrapped in the CuO NPs@ GPTMS@HA-FA for the targeted delivery of cancer therapy.

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Acknowledgements

The authors would like to acknowledge Islamic Azad University (Science and Research Branch) for financial support of this project.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Amir Majd & Amir Heydarinasab

  2. Department of Biochemistry and Biophysics, Varamin (Pishva) Branch, Islamic Azad University, Varamin, 3381774895, Iran

    Raheleh Safaeijavan

  3. Department of Chemistry, Varamin (Pishva) Branch, Islamic Azad University, Varamin, Iran

    Elham Moniri

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  1. Amir Majd
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Contributions

AM: Methodology, conceptualization, investigation, formal analysis, validation, writing-original draft. RS: Supervision, project administration, formal analysis, validation, writing-original draft. AH: Supervision, project administration, formal analysis, validation, writing-original draft. EM: Project administration, formal analysis, writing-review and editing, investigation.

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Correspondence to Raheleh Safaeijavan.

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Majd, A., Safaeijavan, R., Heydarinasab, A. et al. Synthesis of Copper Oxide Nanoparticles Coated on 3-Glycidoxypropyltrimethoxysilane /Folic Acid/ Hyaluronic Acid, and Its Application as Drug Delivery System: Kinetics, Equilibrium, and Thermodynamic Studies. J Clust Sci 34, 3135–3146 (2023). https://doi.org/10.1007/s10876-023-02453-4

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