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Application of Plant Polysaccharide Nanoparticles as Polymeric Carrier Materials for the Construction of Medicine Carriers

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Abstract

Nanoparticle-based drug delivery systems have become a favourable platform for target specificity in disease treatment, although their side effects and toxicity remain controversial. Plant polysaccharide nanoparticles are safe, natural biomaterials that have become candidate materials for nano-drug delivery systems due to their excellent biodegradability and biocompatibility. In addition to becoming candidate materials, plant polysaccharide nanoparticles show excellent pharmacokinetic and drug delivery characteristics as carrier materials to manipulate small drug molecules at the nanoscale, mainly improving medicine solubility, reducing medicine toxicity and side effects and enhancing biological targeting of medicines. Therefore, the application of plant polysaccharide nanoparticles in the field of drug delivery systems may become the focus of future studies. Here we review the carrier function of plant polysaccharide nanoparticles as a polymeric material in drug delivery. The limitations and challenges of applying plant polysaccharide nanoparticles in drug carrier systems are highlighted with the aim to provide a reference for their precise development.

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Funding

This investigation was supported by the Yunnan Province Natural Science Foundation Project (202101AT070274) and Young Scientists Fund of the National Natural Science Foundation of China (82104403).

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  1. Huanhuan Zhao and Qingyu Li have contributed equally to this work.

Authors and Affiliations

  1. Department of Basic Medical, Yunnan University of Chinese Medicine, Kunming, 650500, China

    Huanhuan Zhao, Anhua Shi, Ji Cui & Junzi Wu

  2. School of Medicine, Jianghan University, Wuhan, 430014, China

    Qingyu Li

  3. School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, 650500, China

    Wenling Chen

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JW and WC were corresponding authors who contributed to the study's conception, design, and revision; HZ prepared the manuscript and wrote the major part of the manuscript; QL participated in some of the manuscript writing and literature collection; JC was responsible for reviewing the literature and collecting relevant materials; AS helped to revise the manuscript. All authors approved the final version of this manuscript.

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Zhao, H., Li, Q., Shi, A. et al. Application of Plant Polysaccharide Nanoparticles as Polymeric Carrier Materials for the Construction of Medicine Carriers. J Clust Sci 34, 2215–2228 (2023). https://doi.org/10.1007/s10876-022-02393-5

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