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Systematic investigations on the biophysical complexation of hydroxyethyl starch 200/0.5 with human serum albumin

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Abstract

Spectroscopic techniques have been used to improve the understanding of the interactions between hydroxyethyl starch (HES) 200/0.5 and human serum albumin (HSA) in a simulated physiological fluid of pH 7.4. It has been revealed that static fluorescence quenching occurred when HSA interacted with HES 200/0.5. The negative value of ΔH° (− 2.39 × 104 J·mol−1) and positive value of ΔS° (30.1 J·mol−1·K−1) suggested electrostatic interaction was the dominating force of the binding reaction between HES 200/0.5 to HSA, and the binding process was proved as a spontaneous one with negative ΔG° values (− 3.34 × 105 J·mol−1 at body temperature). The distance between HSA and HES 200/0.5 (r = 2.11 nm) proved efficient energy transfer from Trp to the drug. Moreover, the binding site of HES 200/0.5 to HSA was confirmed by site marker competitive experiments as Sudlow’s site I. Finally, it was observed that the conformation of HSA was changed with a loss of α-helical but acquisition of β contents, where a more stabilized secondary structure was formed.

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Acknowledgements

The authors thank the Medical and Health Technology Development Project of Shandong Province (No. 202013010367) and Yantai Technology and Innovation Development Scheme (No. 2021MSGY048) for financial support.

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  1. Jianzhong Zhang and Tianyi Wang shared First authorship.

Authors and Affiliations

  1. Department of Anesthesiology, Yantaishan Hospital, Yantai, 264000, People’s Republic of China

    Jianzhong Zhang, Shaoyan Huang & Jie Li

  2. Department of Anesthesiology, Dongying Honggang Hospital, Dongying, 257000, People’s Republic of China

    Tianyi Wang

  3. Department of Anesthesiology, People’s Hospital of Dongying, Dongying, 257091, People’s Republic of China

    Huashan Ma

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  1. Jianzhong Zhang
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Contributions

JZ: Conceptualization, Methodology, Investigation, Writing—original draft. TW: Conceptualization, Methodology, Investigation, Writing—original draft. SH: Conceptualization, Methodology, Writing—review & editing. JL: Conceptualization, Writing—review & editing. HM: Conceptualization, Methodology, Investigation, Writing—original draft, Writing—review & editing.

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Correspondence to Huashan Ma.

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Zhang, J., Wang, T., Huang, S. et al. Systematic investigations on the biophysical complexation of hydroxyethyl starch 200/0.5 with human serum albumin. J Incl Phenom Macrocycl Chem 102, 743–750 (2022). https://doi.org/10.1007/s10847-022-01155-0

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  • DOI: https://doi.org/10.1007/s10847-022-01155-0

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