Abstract
Purpose
To perform a pilot study to evaluate the role of sub-silicone oil Triamcinolone Acetonide (TA) crystal drops in complex Retinal Detachment (RD) with extreme proliferative vitreoretinopathy (PVR) requiring 360-degree relaxing retinectomy (RR).
Design
It was a retrospective pilot study.
Materials and methods
It was a retrospective case–control pilot study. TA-assisted 23G or 25G vitrectomy was done in 24 complex RDs with extreme PVR where 360 degree RR had to be performed. Group A (n = 13) included cases where additional TA crystal drops were applied, after settling the detached retina, over the site of RR under silicone oil (SO 5000 CSt) tamponade. In the control arm, group B (n = 11), additional TA crystals were not applied.
Main outcomes measured.
Mean pre- and post-operative BCVA, ultra-widefield fundus photograph by Optos 200Tx, macular OCT and the propensity to remove silicone oil were measured.
Results
Mean pre-operative and post-operative BCVA at final follow-up were Log MAR 2.69 ± 0.41 and Log MAR 1.51 ± 0.90 (Mann–Whitney U test, p < 0.05), respectively, in Group A and Log MAR 2.9 and Log MAR 2.37 ± 0.86 (Mann–Whitney U test, p < 0.05), respectively, in group B. Visual improvement in group A was significantly better than group B (Wilcoxon W test, p < 0.025) with significantly less recurrence of RD (Fisher’s Exact Test, p = 0.002). Silicone oil removal was done significantly more in group A (Fisher’s Exact Test, p = 0.0017).
Conclusion
Sub-silicone oil crystals application over sites of RR after 360-degree relaxing retinectomy leads to improved postoperative visual recovery as well as improved anatomical outcomes with fewer complications.
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Acknowledgements
For statistical analysis: Anup Diwanji and Bimal Roy, Indian Statistical Institute
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Disha Eye Hospitals Pvt Ltd Ethics Committee (Registration No. ECR/876/Inst/WB/2016/RR-19) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Video 1: Shows surgical technique of sub-silicone oil application of TA crystal drops after 360-degree RR which was applied in Group A and not in Group B (M4V 34071 kb)
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Boral, S.K., Agarwal, D., Das, A. et al. Complete manuscript title: role of sub-silicone oil application of triamcinolone acetonide (TA) drops on outcomes after 360° relaxing retinectomy: a pilot study. Int Ophthalmol 43, 1867–1876 (2023). https://doi.org/10.1007/s10792-022-02586-x
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DOI: https://doi.org/10.1007/s10792-022-02586-x