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A Preliminary Study of Applying Chemical Biliary Duct Embolization to Chemical Hepatectomy in Rats

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Abstract

The high recurrence of hepatolithiasis, together with the high operative risk of hepatectomy for specially located stones, has not been settled effectively to date. Thus, this study was designed to investigate the feasibility of applying chemical biliary duct embolization (CBDE) to chemical hepatectomy in rats. As revealed in our results, the intrahepatic biliary ducts could be partially or completely occluded by both phenol and absolute ethanol. In addition, the embolization effect was greatly enhanced by further using cyanoacrylate. Also noteworthy is that CBDE resulted in massive death of hepatocytes, which were replaced by proliferated bile ductules and collagen. More importantly, the hepatocytes disappeared completely in the periphery of the embolized lobe where chemical hepatectomy was achieved. As for the comparison of embolic agents, the combination of phenol and cyanoacrylate exhibited even better fibrogenic effects than the combination of ethanol and cyanoacrylate. In conclusion, CBDE might be a promising approach for achieving the effects of chemical hepatectomy. The combination of phenol and cyanoacrylate potentially acted as a more effective agent for biliary duct embolization.

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Authors and Affiliations

  1. Department of Hepatobiliary Surgery, The Third Medical Military University, Chongqing, China

    Fu Yu Li MD, Sheng He MD, Ning Li MD, Li Sheng Jiang MD, Nan Sheng Cheng MD & **an Zhe **ong MD

  2. Center for Transplantation Immunology, West China Hospital of Sichuan University, The Third Medical Military University, Chongqing, China

    **g Qiu Cheng PhD & Ming Ming Zhang PhD

  3. Department of Hepatobiliary Surgery, Southwest Hospital, The Third Medical Military University, Chongqing, China

    Jia Hong Dong MD

  4. Department of Hepatobiliary Surgery, West China Hospital, Chengdu, 610041, China

    Sheng He MD

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  1. Fu Yu Li MD
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  2. **g Qiu Cheng PhD
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  3. Sheng He MD
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  4. Ning Li MD
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  5. Ming Ming Zhang PhD
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  7. Li Sheng Jiang MD
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  9. **an Zhe **ong MD
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Correspondence to Sheng He MD.

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Li, F.Y., Cheng, J.Q., He, S. et al. A Preliminary Study of Applying Chemical Biliary Duct Embolization to Chemical Hepatectomy in Rats. Dig Dis Sci 50, 1161–1165 (2005). https://doi.org/10.1007/s10620-005-2725-3

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  • DOI: https://doi.org/10.1007/s10620-005-2725-3

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