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new simple and one-pot synthetic routes to polyfunctionally substituted imidazo-[1,2-a]pyridines, pyrido[1,2-a]pyrimidines, pyrido-[1,2-a]-1,3-diazepines, and imidazo[1,2-a]pyrimidines

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Abstract

Reactions of arylidenemalononitriles with 2-nitromethylene-substituted imidazolidine, hexahydropyrimidine, and hexahydro-1,3-diazepine afforded the title derivatives. Reaction of 2-nitromethylenehexahydropyrimidine with benzylamine or n-butylamine and formalin in a molar ratio of 1:1:2 gave the hexahydro-1H-imidazo[1,2-c]pyrimidine derivatives. Treatment of 2-nitromethyleneimidazolidine and hexahydropyrimidine with secondary aliphatic amines and formalin in a molar ratio of 1:1:1 afforded the corresponding methylene bis-compounds.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Mansoura, Mansoura, Egypt

    M. Hammouda, Z. M. Abou Zeid & M. A. Metwally

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  1. M. Hammouda
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  2. Z. M. Abou Zeid
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  3. M. A. Metwally
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Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1850–1853, December, 2005.

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Hammouda, M., Abou Zeid, Z.M. & Metwally, M.A. new simple and one-pot synthetic routes to polyfunctionally substituted imidazo-[1,2-a]pyridines, pyrido[1,2-a]pyrimidines, pyrido-[1,2-a]-1,3-diazepines, and imidazo[1,2-a]pyrimidines. Chem Heterocycl Compd 41, 1525–1528 (2005). https://doi.org/10.1007/s10593-006-0031-4

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  • DOI: https://doi.org/10.1007/s10593-006-0031-4

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