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A carbon-carbon composite implant with a bioceramic coating: assessment of biological reactions using histological and tomographic methods

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Biomedical Engineering Aims and scope

Abstract

This report describes studies using a model of subcutaneous implantation in mice to study the biological reactions occurring around carbon-carbon composite implants coated with non-stoichiometric hydroxyapatite with subsequent annealing. Histological and X-ray studies showed that the coating preparation technique stimulates a number of biological reactions in the body in model animals, leading to an increase in the bioresorption efficiency of the implanted structure. The study results are useful for assessing the prospects for the use of carbon implants and methods for stimulating the required biological reactions.

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Acknowledgements

The authors thank P. A. Tsygankov for advice on methods of application and investigation of the individual parameters of composites, V. V. Zherdeva for analysis of MRI data, and N. S. Sergeeva, I. K. Sviridova, V. A. Kirsanova, and S. A. Akhmetova for analysis of histological preparations.

Funding

The study was supported by the Russian Science Foundation No. 20-79-10190, https://rscf.ru/project/23-79-50005/.

Author information

Authors and Affiliations

  1. Power Engineering Department, Bauman Moscow State Technical University, Moscow, Russian Federation

    A. S. Skriabin, A. V. Shakurov, V. R. Vesnin & E. S. Skriabina

  2. Molecular Imaging Laboratory, Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russian Federation

    V. V. Zherdeva

  3. School of Physics, Universidad Industrial de Santander, Bucaramanga, Colombia

    P. A. Tsygankov

  4. Laboratory for the Prognostication of Conservative Therapy, P.A. Herzen Moscow Research Oncology Institute, Branch of FSBI “National Medical Research Radiological Centre”, Ministry of Health of the Russian Federation, Moscow, Russian Federation

    I. K. Sviridova, V. A. Kirsanova, S. A. Akhmedova & N. S. Sergeeva

Authors
  1. A. S. Skriabin
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  2. V. V. Zherdeva
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  3. P. A. Tsygankov
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  4. A. V. Shakurov
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  5. V. R. Vesnin
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  6. E. S. Skriabina
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  7. I. K. Sviridova
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  8. V. A. Kirsanova
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  9. S. A. Akhmedova
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  10. N. S. Sergeeva
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Corresponding author

Correspondence to A. S. Skriabin.

Additional information

Translated from Meditsinskaya Tekhnika, Vol. 58, No. 2, pp. 4–6, March-April, 2024.

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Skriabin, A.S., Zherdeva, V.V., Tsygankov, P.A. et al. A carbon-carbon composite implant with a bioceramic coating: assessment of biological reactions using histological and tomographic methods. Biomed Eng (2024). https://doi.org/10.1007/s10527-024-10371-6

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  • DOI: https://doi.org/10.1007/s10527-024-10371-6

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