Abstract
Mitochondria are dynamic organelles that participate in different cellular process that control metabolism, cell division, and survival, and the kidney is one of the most metabolically active organs that contains abundant mitochondria. Perturbations in mitochondrial homeostasis in the kidney can accelerate kidney aging, and maintaining mitochondrial homeostasis can effectively delay aging in the kidney. Kidney aging is a degenerative process linked to detrimental processes. The significance of aberrant mitochondrial homeostasis in renal aging has received increasing attention. However, the contribution of mitochondrial quality control (MQC) to renal aging has not been reviewed in detail. Here, we generalize the current factors contributing to renal aging, review the alterations in MQC during renal injury and aging, and analyze the relationship between mitochondria and intrinsic renal cells. We also introduce MQC in the context of renal aging, and discuss the study of mitochondria in the intrinsic cells of the kidney, which is the innovation of our paper. In addition, during kidney injury and repair, the specific functions and regulatory mechanisms of MQC systems in resident and circulating cell types remain unclear. Currently, most of the studies we reviewed are based on animal and cellular models, the relationship between renal tissue aging and mitochondria has not been adequately investigated in clinical studies, and there is still a long way to go.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Abate M, Festa A, Falco M, Lombardi A, Luce A, Grimaldi A, Misso G (2020) Mitochondria as playmakers of apoptosis, autophagy and senescence. Semin Cell Dev Biol 98:139–153. https://doi.org/10.1016/j.semcdb.2019.05.022
Al-Kafaji G, Sabry MA, Skrypnyk C (2016) Time-course effect of high-glucose-induced reactive oxygen species on mitochondrial biogenesis and function in human renal mesangial cells. Cell Biol Int 40(1):36–48. https://doi.org/10.1002/cbin.10520
Baltanas A, Solesio ME, Zalba G, Galindo MF, Fortuno A, Jordan J (2013) The senescence-accelerated mouse prone-8 (SAM-P8) oxidative stress is associated with upregulation of renal NADPH oxidase system. J Physiol Biochem 69(4):927–935. https://doi.org/10.1007/s13105-013-0271-6
Barker SL, Pastor J, Carranza D, Quinones H, Griffith C, Goetz R, Sidhu SS (2015) The demonstration of alphaKlotho deficiency in human chronic kidney disease with a novel synthetic antibody. Nephrol Dial Transplant 30(2):223–233. https://doi.org/10.1093/ndt/gfu291
Benigni A, Perico L, Macconi D (2016) Mitochondrial dynamics is linked to longevity and protects from end-organ injury: the emerging role of sirtuin 3. Antioxid Redox Signal 25(4):185–199. https://doi.org/10.1089/ars.2016.6682
Bharath LP, Agrawal M, McCambridge G, Nicholas DA, Hasturk H, Liu J, Nikolajczyk BS (2020) Metformin enhances autophagy and normalizes mitochondrial function to alleviate aging-associated inflammation. Cell Metab 32(1):44–55. https://doi.org/10.1016/j.cmet.2020.04.015
Bridges CC, Zalups RK (2017) The aging kidney and the nephrotoxic effects of mercury. J Toxicol Environ Health B 20(2):55–80. https://doi.org/10.1080/10937404.2016.1243501
Bunch H, Lawney BP, Lin YF, Asaithamby A, Murshid A, Wang YE, Calderwood SK (2015) Transcriptional elongation requires DNA break-induced signalling. Nat Commun 6:10191. https://doi.org/10.1038/ncomms10191
Casalena GA, Yu L, Gil R, Rodriguez S, Sosa S, Janssen W, Daehn IS (2020) The diabetic microenvironment causes mitochondrial oxidative stress in glomerular endothelial cells and pathological crosstalk with podocytes. Cell Commun Signal 18(1):105. https://doi.org/10.1186/s12964-020-00605-x
Chang-Panesso M (2021) Acute kidney injury and aging. Pediatr Nephrol 36(10):2997–3006. https://doi.org/10.1007/s00467-020-04849-0
Chen K, Dai H, Yuan J, Chen J, Lin L, Zhang W, He Y (2018) Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy. Cell Death Dis 9(2):105. https://doi.org/10.1038/s41419-017-0127-z
Chen MS, Lee RT, Garbern JC (2022a) Senescence mechanisms and targets in the heart. Cardiovasc Res 118(5):1173–1187. https://doi.org/10.1093/cvr/cvab161
Chen Y, Yang Y, Liu Z, He L (2022b) Adiponectin promotes repair of renal tubular epithelial cells by regulating mitochondrial biogenesis and function. Metabolism 128:154959. https://doi.org/10.1016/j.metabol.2021.154959
Cheng H, Fan X, Lawson WE, Paueksakon P, Harris RC (2015) Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy. Kidney Int 88(1):85–94. https://doi.org/10.1038/ki.2015.69
Dai W, Lu H, Chen Y, Yang D, Sun L, He L (2021) The loss of mitochondrial quality control in diabetic kidney disease. Front Cell Dev Biol 9:706832. https://doi.org/10.3389/fcell.2021.706832
Denic A, Glassock RJ, Rule AD (2016) Structural and functional changes with the aging kidney. Adv Chronic Kidney Dis 23(1):19–28. https://doi.org/10.1053/j.ackd.2015.08.004
D’Onofrio N, Servillo L, Giovane A, Casale R, Vitiello M, Marfella R, Balestrieri ML (2016) Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: involvement of SIRT1 and SIRT6. Free Radic Biol Med 96:211–222. https://doi.org/10.1016/j.freeradbiomed.2016.04.013
Duann P, Lin PH (2017) Mitochondria damage and kidney disease. Adv Exp Med Biol 982:529–551. https://doi.org/10.1007/978-3-319-55330-6_27
Dupre TV, Jenkins DP, Muise-Helmericks RC, Schnellmann RG (2019) The 5-hydroxytryptamine receptor 1F stimulates mitochondrial biogenesis and angiogenesis in endothelial cells. Biochem Pharmacol 169:113644. https://doi.org/10.1016/j.bcp.2019.113644
Ebert T, Pawelzik SC, Witasp A, Arefin S, Hobson S, Kublickiene K, Stenvinkel P (2020) Inflammation and premature ageing in chronic kidney disease. Toxins 12(4):12040227. https://doi.org/10.3390/toxins12040227
Fan Y, **a J, Jia D, Zhang M, Zhang Y, Huang G, Wang Y (2016) Mechanism of ginsenoside Rg1 renal protection in a mouse model of d-galactose-induced subacute damage. Pharm Biol 54(9):1815–1821. https://doi.org/10.3109/13880209.2015.1129543
Fang Y, Gong AY, Haller ST, Dworkin LD, Liu Z, Gong R (2020) The ageing kidney: molecular mechanisms and clinical implications. Ageing Res Rev 63:101151. https://doi.org/10.1016/j.arr.2020.101151
Fontecha-Barriuso M, Martin-Sanchez D, Martinez-Moreno JM, Monsalve M, Ramos AM, Sanchez-Nino MD, Sanz AB (2020) The role of PGC-1alpha and mitochondrial biogenesis in kidney diseases. Biomolecules 10(2):347. https://doi.org/10.3390/biom10020347
Fougeray S, Pallet N (2015) Mechanisms and biological functions of autophagy in diseased and ageing kidneys. Nat Rev Nephrol 11(1):34–45. https://doi.org/10.1038/nrneph.2014.201
Franzin R, Stasi A, Ranieri E, Netti GS, Cantaluppi V, Gesualdo L, Castellano G (2021) Targeting premature renal aging: from molecular mechanisms of cellular senescence to senolytic trials. Front Pharmacol 12:630419. https://doi.org/10.3389/fphar.2021.630419
Gao X, Yu X, Zhang C, Wang Y, Sun Y, Sun H, He X (2022) Telomeres and mitochondrial metabolism: implications for cellular senescence and age-related diseases. Stem Cell Rev Rep 18(7):2315–2327. https://doi.org/10.1007/s12015-022-10370-8
Giacomello M, Pyakurel A, Glytsou C, Scorrano L (2020) The cell biology of mitochondrial membrane dynamics. Nat Rev Mol Cell Biol 21(4):204–224. https://doi.org/10.1038/s41580-020-0210-7
Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A (2017) Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment. CNS Neurosci Ther 23(1):5–22. https://doi.org/10.1111/cns.12655
Hernandez-Segura A, Nehme J, Demaria M (2018) Hallmarks of cellular senescence. Trends Cell Biol 28(6):436–453. https://doi.org/10.1016/j.tcb.2018.02.001
Higgins GC, Coughlan MT (2014) Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy? Br J Pharmacol 171(8):1917–1942. https://doi.org/10.1111/bph.12503
Hommos MS, Glassock RJ, Rule AD (2017) Structural and functional changes in human kidneys with healthy aging. J Am Soc Nephrol 28(10):2838–2844. https://doi.org/10.1681/ASN.2017040421
Hongbo M, Yanjiao D, Shuo W, Kun S, Yanjie L, Mengmeng L (2021) Podocyte RNF166 deficiency alleviates diabetic nephropathy by mitigating mitochondria impairment and apoptosis via regulation of CYLD signal. Biochem Biophys Res Commun 545:46–53. https://doi.org/10.1016/j.bbrc.2020.12.014
Isik B, Thaler R, Goksu BB, Conley SM, Al-Khafaji H, Mohan A, Herrmann SM (2021) Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis. Stem Cell Res Ther 12(1):240. https://doi.org/10.1186/s13287-021-02310-z
Jiang N, Zhao H, Han Y, Li L, **ong S, Zeng L, Sun L (2020) HIF-1alpha ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics. Cell Prolif 53(11):e12909. https://doi.org/10.1111/cpr.12909
** L, Yu B, Liu G, Nie W, Wang J, Chen J, Yang Y (2022) Mitophagy induced by UMI-77 preserves mitochondrial fitness in renal tubular epithelial cells and alleviates renal fibrosis. FASEB J 36(6):e22342. https://doi.org/10.1096/fj.202200199RR
Karnewar S, Neeli PK, Panuganti D, Kotagiri S, Mallappa S, Jain N, Kotamraju S (2018) Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction. Biochim Biophys Acta Mol Basis Dis 1864(4 Pt A):1115–1128. https://doi.org/10.1016/j.bbadis.2018.01.018
Konari N, Nagaishi K, Kikuchi S, Fujimiya M (2019) Mitochondria transfer from mesenchymal stem cells structurally and functionally repairs renal proximal tubular epithelial cells in diabetic nephropathy in vivo. Sci Rep 9(1):5184. https://doi.org/10.1038/s41598-019-40163-y
Korolchuk VI, Miwa S, Carroll B, von Zglinicki T (2017) Mitochondria in cell senescence: is mitophagy the weakest link? EBioMedicine 21:7–13. https://doi.org/10.1016/j.ebiom.2017.03.020
Kritsilis M, Rizou S, Koutsoudaki PN, Evangelou K, Gorgoulis VG, Papadopoulos D (2018) Ageing, cellular senescence and neurodegenerative disease. Int J Mol Sci 19(10):19102937. https://doi.org/10.3390/ijms19102937
Kulkarni AS, Gubbi S, Barzilai N (2020) Benefits of metformin in attenuating the hallmarks of aging. Cell Metab 32(1):15–30. https://doi.org/10.1016/j.cmet.2020.04.001
Leduc-Gaudet JP, Hussain SNA, Barreiro E, Gouspillou G (2021) Mitochondrial dynamics and mitophagy in skeletal muscle health and aging. Int J Mol Sci 22(15):8179. https://doi.org/10.3390/ijms22158179
Lee JH, Yoon YM, Song KH, Noh H, Lee SH (2020) Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L-mitophagy pathway. Aging Cell 19(3):e13111. https://doi.org/10.1111/acel.13111
Lee HW, Xu Y, He L, Choi W, Gonzalez D, ** SW, Simons M (2021) Role of venous endothelial cells in developmental and pathologic angiogenesis. Circulation 144(16):1308–1322. https://doi.org/10.1161/circulationaha.121.054071
Leon KE, Buj R, Lesko E, Dahl ES, Chen CW, Tangudu NK, Aird KM (2021) DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A. J Cell Biol 220(8):e202008101. https://doi.org/10.1083/jcb.202008101
Li SY, Susztak K (2018) The role of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) in kidney disease. Semin Nephrol 38(2):121–126. https://doi.org/10.1016/j.semnephrol.2018.01.003
Li Y, Pan Y, Cao S, Sasaki K, Wang Y, Niu A, Harris RC (2021a) Podocyte EGFR inhibits autophagy through upregulation of rubicon in Type 2 diabetic nephropathy. Diabetes 70(2):562–576. https://doi.org/10.2337/db20-0660
Li Z, Lu S, Li X (2021b) The role of metabolic reprogramming in tubular epithelial cells during the progression of acute kidney injury. Cell Mol Life Sci 78(15):5731–5741. https://doi.org/10.1007/s00018-021-03892-w
Lin Q, Li S, Jiang N, Shao X, Zhang M, ** H, Ni Z (2019) PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation. Redox Biol 26:101254. https://doi.org/10.1016/j.redox.2019.101254
Liu L, Bai F, Song H, **ao R, Wang Y, Yang H, Liang X (2022a) Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy. Redox Biol 50:102260. https://doi.org/10.1016/j.redox.2022.102260
Liu Q, Chang CE, Wooldredge AC, Fong B, Kennedy BK, Zhou C (2022b) Tom70-based transcriptional regulation of mitochondrial biogenesis and aging. elife 11:e75658. https://doi.org/10.7554/eLife.75658
Liu S, Yuan Y, Xue Y, **ng C, Zhang B (2022c) Podocyte injury in diabetic kidney disease: a focus on mitochondrial dysfunction. Front Cell Dev Biol 10:832887. https://doi.org/10.3389/fcell.2022.832887
Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G (2023) Hallmarks of aging: an expanding universe. Cell 186(2):243–278. https://doi.org/10.1016/j.cell.2022.11.001
Madreiter-Sokolowski CT, Sokolowski AA, Waldeck-Weiermair M, Malli R, Graier WF (2018) Targeting mitochondria to counteract age-related cellular dysfunction. Genes 9(3):165. https://doi.org/10.3390/genes9030165
Manczak M, Kandimalla R, Yin X, Reddy PH (2019) Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity. Hum Mol Genet 28(2):177–199. https://doi.org/10.1093/hmg/ddy335
Martínez-Reyes I, Chandel NS (2020) Mitochondrial TCA cycle metabolites control physiology and disease. Nat Commun 11(1):102. https://doi.org/10.1038/s41467-019-13668-3
Mattson MP, Arumugam TV (2018) Hallmarks of brain aging: adaptive and pathological modification by metabolic states. Cell Metab 27(6):1176–1199. https://doi.org/10.1016/j.cmet.2018.05.011
Miao J, Liu J, Niu J, Zhang Y, Shen W, Luo C, Zhou L (2019) Wnt/beta-catenin/RAS signaling mediates age-related renal fibrosis and is associated with mitochondrial dysfunction. Aging Cell 18(5):e13004. https://doi.org/10.1111/acel.13004
Miao J, Huang J, Luo C, Ye H, Ling X, Wu Q, Zhou L (2021) Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells. Physiol Rep 9(2):e14696. https://doi.org/10.14814/phy2.14696
Miwa S, Kashyap S, Chini E, von Zglinicki T (2022) Mitochondrial dysfunction in cell senescence and aging. J Clin Invest. https://doi.org/10.1172/JCI158447
Morigi M, Perico L, Benigni A (2018) Sirtuins in renal health and disease. J Am Soc Nephrol 29(7):1799–1809. https://doi.org/10.1681/ASN.2017111218
Ni HM, Williams JA, Ding WX (2015) Mitochondrial dynamics and mitochondrial quality control. Redox Biol 4:6–13. https://doi.org/10.1016/j.redox.2014.11.006
Phadwal K, Vrahnas C, Ganley IG, MacRae VE (2021) Mitochondrial dysfunction: cause or consequence of vascular calcification? Front Cell Dev Biol 9:611922. https://doi.org/10.3389/fcell.2021.611922
Picca A, Mankowski RT, Burman JL, Donisi L, Kim JS, Marzetti E, Leeuwenburgh C (2018) Mitochondrial quality control mechanisms as molecular targets in cardiac ageing. Nat Rev Cardiol 15(9):543–554. https://doi.org/10.1038/s41569-018-0059-z
Qi H, Casalena G, Shi S, Yu L, Ebefors K, Sun Y, Daehn I (2017a) Glomerular endothelial mitochondrial dysfunction is essential and characteristic of diabetic kidney disease susceptibility. Diabetes 66(3):763–778. https://doi.org/10.2337/db16-0695
Qi W, Keenan HA, Li Q, Ishikado A, Kannt A, Sadowski T, King GL (2017b) Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nat Med 23(6):753–762. https://doi.org/10.1038/nm.4328
Qin X, Zhao Y, Gong J, Huang W, Su H, Yuan F, Lu F (2019) Berberine protects glomerular podocytes via inhibiting Drp1-mediated mitochondrial fission and dysfunction. Theranostics 9(6):1698–1713. https://doi.org/10.7150/thno.30640
Quadri MM, Fatima SS, Che RC, Zhang AH (2019) Mitochondria and renal fibrosis. Adv Exp Med Biol 1165:501–524. https://doi.org/10.1007/978-981-13-8871-2_25
Ramachandran S, Haddad D, Li C, Le MX, Ling AK, So CC, Martin A (2016) The SAGA deubiquitination module promotes DNA repair and class switch recombination through ATM and DNAPK-mediated gammaH2AX formation. Cell Rep 15(7):1554–1565. https://doi.org/10.1016/j.celrep.2016.04.041
Reznick RM, Zong H, Li J, Morino K, Moore IK, Yu HJ, Shulman GI (2007) Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metab 5(2):151–156. https://doi.org/10.1016/j.cmet.2007.01.008
<Senescence and the SASP many therapeutic avenues.pdf>. https://doi.org/10.1101/gad.343129
Shmulevich R, Krizhanovsky V (2021) Cell senescence, DNA damage, and metabolism. Antioxid Redox Signal 34(4):324–334. https://doi.org/10.1089/ars.2020.8043
Slavin MB, Kumari R, Hood DA (2022) ATF5 is a regulator of exercise-induced mitochondrial quality control in skeletal muscle. Mol Metab 66:101623. https://doi.org/10.1016/j.molmet.2022.101623
Small DM, Bennett NC, Roy S, Gabrielli BG, Johnson DW, Gobe GC (2012) Oxidative stress and cell senescence combine to cause maximal renal tubular epithelial cell dysfunction and loss in an in vitro model of kidney disease. Nephron Exp Nephrol 122(3–4):123–130. https://doi.org/10.1159/000350726
Sun J, Zhu H, Wang X, Gao Q, Li Z, Huang H (2019) CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy. J Endocrinol. https://doi.org/10.1530/joe-18-0578
Takabatake Y, Kimura T, Takahashi A, Isaka Y (2014) Autophagy and the kidney: health and disease. Nephrol Dial Transplant 29(9):1639–1647. https://doi.org/10.1093/ndt/gft535
Tan J, **e Q, Song S, Miao Y, Zhang Q (2018) Albumin overload and PINK1/parkin signaling-related mitophagy in renal tubular epithelial cells. Med Sci Monit 24:1258–1267. https://doi.org/10.12659/msm.907718
Tang X, Li PH, Chen HZ (2020) Cardiomyocyte senescence and cellular communications within myocardial microenvironments. Front Endocrinol 11:280. https://doi.org/10.3389/fendo.2020.00280
Tang C, Cai J, Yin XM, Weinberg JM, Venkatachalam MA, Dong Z (2021) Mitochondrial quality control in kidney injury and repair. Nat Rev Nephrol 17(5):299–318. https://doi.org/10.1038/s41581-020-00369-0
<The pathogenesis of diabetic nephropathy.pdf>
Typiak M, Piwkowska A (2021) Antiinflammatory actions of Klotho: implications for therapy of diabetic nephropathy. Int J Mol Sci 22(2):956. https://doi.org/10.3390/ijms22020956
Wai T, Langer T (2016) Mitochondrial dynamics and metabolic regulation. Trends Endocrinol Metab 27(2):105–117. https://doi.org/10.1016/j.tem.2015.12.001
Wang W, Wang Y, Long J, Wang J, Haudek SB, Overbeek P, Danesh FR (2012) Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metab 15(2):186–200. https://doi.org/10.1016/j.cmet.2012.01.009
Wang Y, Wang Y, Yang M, Ma X (2021) Implication of cellular senescence in the progression of chronic kidney disease and the treatment potencies. Biomed Pharmacother 135:111191. https://doi.org/10.1016/j.biopha.2020.111191
Wei PZ, Szeto CC (2019) Mitochondrial dysfunction in diabetic kidney disease. Clin Chim Acta 496:108–116. https://doi.org/10.1016/j.cca.2019.07.005
Wu M, Gu X, Ma Z (2021a) Mitochondrial quality control in cerebral ischemia-reperfusion injury. Mol Neurobiol 58(10):5253–5271. https://doi.org/10.1007/s12035-021-02494-8
Wu XQ, Zhang DD, Wang YN, Tan YQ, Yu XY, Zhao YY (2021b) AGE/RAGE in diabetic kidney disease and ageing kidney. Free Radic Biol Med 171:260–271. https://doi.org/10.1016/j.freeradbiomed.2021.05.025
Wu D, Ji H, Du W, Ren L, Qian G (2022) Mitophagy alleviates ischemia/reperfusion-induced microvascular damage through improving mitochondrial quality control. Bioengineered 13(2):3596–3607. https://doi.org/10.1080/21655979.2022.2027065
**ao L, Xu X, Zhang F, Wang M, Xu Y, Tang D, Sun L (2017) The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1. Redox Biol 11:297–311. https://doi.org/10.1016/j.redox.2016.12.022
**ong Y, Zhou L (2019) The signaling of cellular senescence in diabetic nephropathy. Oxid Med Cell Longev 2019:7495629. https://doi.org/10.1155/2019/7495629
Xu L, Wang J, Yu H, Mei H, He P, Wang M, Liu F (2023) GLIS1 alleviates cell senescence and renal fibrosis through PGC1-α mediated mitochondrial quality control in kidney aging. Free Radic Biol Med 209:171–184. https://doi.org/10.1016/j.freeradbiomed.2023.09.037
Yang M, Liu C, Jiang N, Liu Y, Luo S, Li C, Sun L (2023) Mitochondrial homeostasis: a potential target for delaying renal aging. Front Pharmacol 14:1191517. https://doi.org/10.3389/fphar.2023.1191517
Yao L, Liang X, Qiao Y, Chen B, Wang P, Liu Z (2022) Mitochondrial dysfunction in diabetic tubulopathy. Metabolism 131:155195. https://doi.org/10.1016/j.metabol.2022.155195
Yi X, Yan W, Guo T, Liu N, Wang Z, Shang J, Chen L (2022) Erythropoietin mitigates diabetic nephropathy by restoring PINK1/parkin-mediated mitophagy. Front Pharmacol 13:883057. https://doi.org/10.3389/fphar.2022.883057
Yu S, Cheng Y, Li B, Xue J, Yin Y, Gao J, Mu Y (2020) M1 macrophages accelerate renal glomerular endothelial cell senescence through reactive oxygen species accumulation in streptozotocin-induced diabetic mice. Int Immunopharmacol 81:106294. https://doi.org/10.1016/j.intimp.2020.106294
Yue L, Yao H (2016) Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases. Br J Pharmacol 173(15):2305–2318. https://doi.org/10.1111/bph.13518
Zhan M, Brooks C, Liu F, Sun L, Dong Z (2013) Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology. Kidney Int 83(4):568–581. https://doi.org/10.1038/ki.2012.441
Zhan M, Usman IM, Sun L, Kanwar YS (2015) Disruption of renal tubular mitochondrial quality control by Myo-inositol oxygenase in diabetic kidney disease. J Am Soc Nephrol 26(6):1304–1321. https://doi.org/10.1681/ASN.2014050457
Zhang MZ, Wang Y, Paueksakon P, Harris RC (2014) Epidermal growth factor receptor inhibition slows progression of diabetic nephropathy in association with a decrease in endoplasmic reticulum stress and an increase in autophagy. Diabetes 63(6):2063–2072. https://doi.org/10.2337/db13-1279
Zhang T, Li J, Zhao G (2021) Quality control mechanisms of mitochondria: another important target for treatment of peripheral neuropathy. DNA Cell Biol 40(12):1513–1527. https://doi.org/10.1089/dna.2021.0529
Zhou D, Zhou M, Wang Z, Fu Y, Jia M, Wang X, Yi F (2019a) PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy. Cell Death Dis 10(7):524. https://doi.org/10.1038/s41419-019-1754-3
Zhou P, **e W, Meng X, Zhai Y, Dong X, Zhang X, Sun X (2019b) Notoginsenoside R1 ameliorates diabetic retinopathy through PINK1-dependent activation of mitophagy. Cells 8(3):213. https://doi.org/10.3390/cells8030213
Zhu J, Wang KZ, Chu CT (2013) After the banquet: mitochondrial biogenesis, mitophagy, and cell survival. Autophagy 9(11):1663–1676. https://doi.org/10.4161/auto.24135
Zhu L, Luo X, Fu N, Chen L (2021) Mitochondrial unfolded protein response: a novel pathway in metabolism and immunity. Pharmacol Res 168:105603. https://doi.org/10.1016/j.phrs.2021.105603
Acknowledgements
This research was supported partly by the Natural Science Foundation of China (No.81800642, 82070754), partly by China Postdoctoral Science Foundation (2021M703608), and partly by Doctoral Scientific Research Foundation of Liaoning Province (20180540113). We want to express our gratitude for the drawing materials provided by BioRebder.
Author information
Authors and Affiliations
Contributions
LX, XG, JW wrote and edited the manuscript. XG and YW prepared the artwork. LX and XZ conceptualized the study and planned the structure and the content of the manuscript. All authors reviewed the manuscript.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Guo, X., Wang, J., Wu, Y. et al. Renal aging and mitochondrial quality control. Biogerontology 25, 399–414 (2024). https://doi.org/10.1007/s10522-023-10091-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10522-023-10091-6