SpringerLink
Log in

Effect of Melatonin on the Content of CD3low and CD3hi T Cells in the Thymus of Mice with Functional Pinealectomy

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Continuous lighting for 14 days (functional pinealectomy model) leads to a decrease in the relative number of CD3low and CD3hi T lymphocytes and the CD3low/CD3hi ratio in the thymus of C57BL/6 mice. Intragastric administration of melatonin in physiological doses (1 mg/kg body weight, 14 days) against the background of functional pinealectomy restores the percentage of CD3low and CD3hi thymocytes and CD3low/CD3hi ratio to the control values. Hence, prolonged continuous illumination inhibits the differentiation and maturation of young thymocytes into mature forms, while melatonin treatment helps to compensate the effects of functional pinealectomy triggering cell proliferation in the thymus from the earliest stages of proliferation and differentiation of T cells. Thus, melatonin has immunotropic properties and can be used for correction of the consequences of functional pinealectomy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Turkowska E, Majewski PM, Rai S, Skwarlo-Sonta K. Pineal oscillator functioning in the chicken — effect of photoperiod and melatonin. Chronobiol. Int. 2014;31(1):134-143. https://doi.org/10.3109/07420528.2013.832279

    Article  CAS  PubMed  Google Scholar 

  2. Pelegrí C, Vilaplana J, Castellote C, Rabanal M, Franch A, Castell M. Circadian rhythms in surface molecules of rat blood lymphocytes. Am. J. Physiol. Cell Physiol. 2003;284(1):C67-C76. https://doi.org/10.1152/ajpcell.00084.2002

    Article  PubMed  Google Scholar 

  3. Jilg A, Bechstein P, Saade A, Dick M, Li TX, Tosini G, Rami A, Zemmar A, Stehle JH. Melatonin modulates daytime-dependent synaptic plasticity and learning efficiency. J. Pineal Res. 2019;66(3):e12553. https://doi.org/10.1111/jpi.12553

  4. Michurina SV, Kolesnikov SI, Ishchenko IY, Arkhipov SA. Light-Induced Functional Pinealectomy: Expression of MT2 Receptors in Liver Cells of C57BL/6 Mice after Melatonin Treatment. Bull. Exp. Biol. Med. 2022;173(4):569-574. https://doi.org/10.1007/s10517-022-05590-4

    Article  CAS  PubMed  Google Scholar 

  5. Michurina SV, Miroshnichenko SM, Serykh AE, Ishchenko IY, Letyagin AY, Zavjalov EL. Light-Induced Functional Pinealectomy. Effect on the Thymus of C57BL/6 Mice. Bull. Exp. Biol. Med. 2022;174(1):152-158. https://doi.org/10.1007/s10517-022-05665-2

  6. Hofmann T, Schmucker SS, Bessei W, Grashorn M, Stefanski V. Impact of Housing Environment on the Immune System in Chickens: A Review. Animals (Basel). 2020;10(7):1138. https://doi.org/10.3390/ani10071138

    Article  PubMed  PubMed Central  Google Scholar 

  7. Kinsella S, Dudakov JA. When the damage is done: injury and repair in thymus function. Front. Immunol. 2020;11:1745. https://doi.org/10.3389/fimmu.2020.01745

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Pivonello C, Negri M, Patalano R, Amatrudo F, Montò T, Liccardi A, Graziadio C, Muscogiuri G, Pivonello R, Colao A. The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review. Obes. Rev. 2022;23(3):e13390. https://doi.org/10.1111/obr.13390

  9. Chen F, Reheman A, Cao J, Wang Z, Dong Y, Zhang Y, Chen Y. Effect of melatonin on monochromatic light-induced T-lymphocyte proliferation in the thymus of chickens. J. Photochem. Photobiol. B. 2016;161:9-16. https://doi.org/10.1016/j.jphotobiol.2016.05.001

    Article  CAS  PubMed  Google Scholar 

  10. Ren W, Liu G, Chen S, Yin J, Wang J, Tan B, Wu G, Bazer FW, Peng Y, Li T, Reiter RJ, Yin Y. Melatonin signaling in T cells: Functions and applications. J. Pineal Res. 2017;62(3):e12394. https://doi.org/10.1111/jpi.12394

  11. Seema R, Chandana H. Melatonin ameliorates oxidative stress and induces cellular proliferation of lymphoid tissues of a tropical rodent, Funambulus pennanti, during reproductively active phase. Protoplasma. 2013;250(1):21-32. https://doi.org/10.1007/s00709-011-0367-1

    Article  CAS  PubMed  Google Scholar 

  12. Luo J, Zhang Z, Sun H, Song J, Chen X, Huang J, Lin X, Zhou R. Effect of melatonin on T/B cell activation and immune regulation in pinealectomy mice. Life Sci. 2020;242:117191. https://doi.org/10.1016/j.lfs.2019.117191

  13. Susko I, Alicelebic S, Cosovic E, Sahinovic M, Kapic D, Custovic S, Muzika V. Gender-related histological changes in the thymus gland after pinealectomy and short-term melatonin treatment in rats. Med. Arch. 2017;71(6):385-390. https://doi.org/10.5455/medarh.2017.71.385-390

    Article  PubMed  PubMed Central  Google Scholar 

  14. El-Bakry HA, Ismail IA, Soliman SS. Immunosenescencelike state is accelerated by constant light exposure and counteracted by melatonin or turmeric administration through DJ-1/Nrf2 and P53/Bax pathways. J. Photochem. Photobiol. B. 2018;186:69-80. https://doi.org/10.1016/j.jphotobiol.2018.07.003

    Article  CAS  PubMed  Google Scholar 

  15. Brazão V, Santello FH, Colato RP, do Prado JC Jr. T. cruzi infection among aged rats: Melatonin as a promising therapeutic molecule. Exp. Gerontol. 2020;135:10922. https://doi.org/10.1016/j.exger.2020.110922

Download references

Author information

Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    S. V. Michurina, S. M. Miroshnichenko, I. Yu. Ishchenko, A. E. Serykh & L. N. Rachkovskaya

  2. Research Institute of Biochemistry, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    S. M. Miroshnichenko

  3. Research Institute of Experimental and Clinical Medicine, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    A. E. Serykh

Authors
  1. S. V. Michurina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. M. Miroshnichenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. Yu. Ishchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. E. Serykh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. N. Rachkovskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. V. Michurina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 12, pp. 728-731, December, 2022

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Michurina, S.V., Miroshnichenko, S.M., Ishchenko, I.Y. et al. Effect of Melatonin on the Content of CD3low and CD3hi T Cells in the Thymus of Mice with Functional Pinealectomy. Bull Exp Biol Med 174, 754–757 (2023). https://doi.org/10.1007/s10517-023-05786-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-023-05786-2

Keywords

Search

Navigation