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Effect of Oligochitosan on Experimental Venous Thrombosis in Guinea Pigs

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Oligochitosan Сh10/85 with a molecular weight of 10 kDa and a deacetylation degree of 85% prevented the development of experimental venous thrombosis in guinea pigs after intravenous administration in a dose of 30 mg/kg. In a concentration of 0.005-0.5 mg/ml, oligochitosan Ch10/85 did not provoke hemolysis of human red blood cells in in vitro experiments. The antithrombotic effect of oligochitosan Ch10/85 that exhibits low anticoagulant activity (by two orders of magnitude lower than that of unfractionated heparin) can be associated with inhibition of platelet aggregation.

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Authors and Affiliations

  1. National Medical Research Center for Hematology, Ministry of Health of the Russian Federation, Moscow, Russia

    N. N. Drozd

  2. Institute of Bioengineering, Federal Research Center Fundamentals of Biotechnology, Russian Academy of Sciences, Moscow, Russia

    A.V. Il’ina, B. Ts. Shagdarova & V. P. Varlamov

Authors
  1. N. N. Drozd
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  2. A.V. Il’ina
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  3. B. Ts. Shagdarova
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  4. V. P. Varlamov
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Corresponding author

Correspondence to N. N. Drozd.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 7, pp. 42-47, July, 2021

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Drozd, N.N., Il’ina, A., Shagdarova, B.T. et al. Effect of Oligochitosan on Experimental Venous Thrombosis in Guinea Pigs. Bull Exp Biol Med 172, 33–37 (2021). https://doi.org/10.1007/s10517-021-05325-x

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  • DOI: https://doi.org/10.1007/s10517-021-05325-x

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