Abstract
Objective
We investigated the expression of insulin-like growth factor-1 (IGF-1) so as to explore its relationship with carcinogenesis and development of breast cancer.
Methods
IGF-1 mRNA levels in tissues of breast cancer, adjacent breast cancer in 70 cases breast cancer patients were analyzed by RT-PCR with the normal breast tissues of paired breast as the control.
Results
The level of IGF-1 mRNA expression in breast cancer tissues was significantly higher than that in the paired adjacent to breast cancer tissues, normal mammary gland tissues. The ration of IGF-1/β-actin were 0.679 ± 0.075, 0.463 ± 0.085, 0.305 ± 0.031, respectively. There was significant difference between different groups (P < 0.005). Expression of IGF-1 was associated with lymph node metastasis, pathological staging and estrogen receptor status of breast cancer and no significant relationship with tumor pathological grou** (P > 0.005).
Conclusion
The high-level expression of IGF-1 in breast cancer tissues is correlated with carcinogenesis, development and metastasis of breast cancer.
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Chen, M., Li, M. & Li, J. Expression of insulin-like growth factor-1 in breast cancer tissues. Chin. -Ger. J. Clin. Oncol. 8, 326–328 (2009). https://doi.org/10.1007/s10330-009-0056-0
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DOI: https://doi.org/10.1007/s10330-009-0056-0