Abstract
Objective
To investigate the correlations of expression of Bax inhibitor-1 (BI-1) gene and the receptors of estrogen and progestogen in breast cancer and its significance.
Methods
Immunohistochemical methods had been used to detect the expressions of BI-1 gene and receptors of estrogen and progestogen in breast cancer.
Results
The positive rates of expressions of BI-1 gene, estrogen receptor (ER) and progestogen receptor (PR) in breast cancer were 77.08%, 60.42% and 54.17%, respectively. The positive rate of expression of BI-1 gene was higher in the group with negative expression of ER than the positive group, their positive rates were 76.92% and 52.27%, respectively; but there was no statistical difference between the two groups with positive and negative expressions of PR. The positive rate of expression of BI-1 gene was also higher in the group with positive lymph node metastasis than the non-lymph node metastasis group, and their positive rates were 64.58% and 36.36%, respectively. The difference was statistically significant (P < 0.05).
Conclusion
BI-1 gene, in combination with ER, has guiding significance for patients with breast cancer to choose individual chemotherapy and radiotherapy after operation and can become an important indicator for judging the prognosis of breast cancer.
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Supported by a grant of Henan Province to support the Medical High-tech Development Project (No. 20060038).
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Li, J., Li, M., Li, J. et al. Expression of BI-1 protein and its significance in breast cancer. Chin. -Ger. J. Clin. Oncol. 8, 160–163 (2009). https://doi.org/10.1007/s10330-008-0101-4
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DOI: https://doi.org/10.1007/s10330-008-0101-4