Résumé
Un grand nombre de biomarqueurs est à l’étude afin de préciser le pronostic de la maladie tumorale, notamment en situation adjuvante où les facteurs clinicopathologiques classiques peuvent faire défaut. La nature de l’infiltrat immunitaire intratumoral et son importance sont étroitement associées à la survie du patient. Tout type de cellule immunitaire peut se retrouver au sein d’une prolifération néoplasique avec une action pro- ou antitumorale. La caractérisation de ces paramètres immunitaires et leur impact sur la survie ont été définis comme la contexture immunitaire. Ainsi, la réponse lymphocytaire Th1 cytotoxique ainsi que la présence de TLS (tertiary lymphoid structures, structures lymphoïdes tertiaires) sont de bon pronostic, tandis qu’une réponse Th2, Th17, les lymphocytes T régulateurs (LTreg) et les TAMs apparaissent de pronostic péjoratif.
Abstract
A lot of biomarkers are under study in order to accurate cancer’s prognosis, especially in adjuvant setting, where classical clinicopathological features appear sometimes to be insufficient. Immune infiltrate is now recognized as tightly correlated to outcomes. All immune cell types may be found in a tumor and may have pro- or antitumoral effects. Characterization of the immune parameters and their correlation to outcomes have been defined as the immune contexture. Thus, the response of cytotoxic Th1 cells and the presence of TLS are associated with good prognosis while, the response of cytotoxic Th2 and Th17 cells and the presence of iTreg or TAMs appear to have pejorative prognosis.
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Abbreviations
- ADCC:
-
antibody dépendent cell-mediated cytotoxicity
- CCR:
-
cancer colorectal
- CD:
-
cellules dendritiques
- CSF:
-
colony-stimulating-factor
- CTL:
-
lymphocytes cytotoxiques
- KIR:
-
killer inhibitory receptor
- LAP:
-
latency-associated peptide
- CMH:
-
complexe majeur d’histocompatibilité
- MSI:
-
instabilité microsatellitaire
- MSS:
-
stabilité microsatellitaire
- pDC:
-
cellules dendritiques plasmatoïdes
- TAA:
-
tumor-associated antigens
- TAM:
-
macrophages associés aux tumeurs
- TCR:
-
T cell receptor
- Th:
-
T-helper
- TLR:
-
toll-like receptor
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Patsouris, A., Bendriss-Vermare, N. Facteurs pronostiques et prédictifs de réponse aux immunothérapies (TILs, TAM). Oncologie 17, 397–401 (2015). https://doi.org/10.1007/s10269-015-2548-6
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DOI: https://doi.org/10.1007/s10269-015-2548-6