Abstract
By the reaction of poly(acryloyl chloride) with N-(3-aminopropyl)imidazole, poly(N-(3-(1H-imidazol-1-yl)propyl)acrylamide) was synthesized. The new polymer contains an imidazole ring removed from the main chain by a spacer of five bonds. The structure and purity, molecular weight, hydrodynamic and thermosensitive properties of the obtained sample were studied by 1H- and 13C-NMR, FTIR spectroscopy, acid-base titration, light scattering, turbidimetry and viscometry. The observed ability of the imidazole-containing polymer to form and destroy associates in water-salt solutions at pH 6.6–7.4 and temperatures of 29–48 °C indicates that these are promising candidates for designing complex biomedical systems. The new polymer is able to form complexes with oligo-DNA more actively than poly(1-vinylimidazole), which is of interest for gene delivery applications. The polymer cross-linked with epichlorohydrin gives micro-relief coatings on the plastic surface, and the modified surface is able to attach negatively charged objects. This thermo- and pH-sensitive polymer modification can be applied to create finely controlled surfaces for cell culturing.
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This work was financially supported by the Russian Science Foundation (No. 22-24-00474).
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Zakharova, N.V., Zelinskiy, S.N., Strelova, M.S. et al. Thermo- and pH-sensitive Polymer with Pendant Spacer-linked Imidazole Cycles. Chin J Polym Sci 42, 437–445 (2024). https://doi.org/10.1007/s10118-023-3056-6
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DOI: https://doi.org/10.1007/s10118-023-3056-6