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The clinical and imaging features of gray matter heterotopia: a clinical analysis on 15 patients

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Abstract

Objective

To investigate the clinical and imaging features of gray matter heterotopia (GMH) and improve the clinicians’ understanding of the disease.

Methods

A retrospective study was performed on 15 patients with GMH diagnosed at The Affiliated Hospital of Xuzhou Medical University from November 2014 to November 2016. Their clinical and imaging features are also summarized.

Results

The proportion of male and female patients was 2:1. The age of onset was 2~45 years and the average age was 19.1 years. There were 13 patients with epilepsy who also had cognitive decline (5 cases) and neurological deficit (3 cases). There were 2 patients with headache or dizziness. The imaging findings of GMH are unilateral or multiple spots in the periventricular or subependymal, subcortical, and centrum semiovale and are often accompanied by other cerebral malformations. We found that 10 patients had the subcortical type of GMH and 5 patients had the subependymal type or periventricular nodular heterotopia type. There were 8 cases of ventricular compression, 5 cases of ventriculomegaly, 5 cases of cerebral fissure malformation, 3 cases of pachygyria, 1 case of callosal agenesis, and 1 case of undeveloped septum pellucidum. All the patients were given symptomatic and supportive therapies and 3 patients were treated with antiepileptic drugs. Seizures were, however, poorly controlled.

Conclusion

GMH should also be suspected in patients with juvenile onset of seizures, cognitive decline, and neurological deficits. Magnetic resonance scans may show lesions in the white matter of the brain with signals similar to the normal gray matter.

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Funding

This paper is supported by the National Natural Science Foundation of China (Grant No. 81271268).

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Author notes

  1. Hafiz Khuram Raza and Hao Chen contributed equally to this work.

Authors and Affiliations

  1. School of International Education, Xuzhou Medical University, Xuzhou, 221004, China

    Hafiz Khuram Raza & Thitsavanh Chansysouphanthong

  2. Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China

    Hafiz Khuram Raza, Hao Chen, Zuohui Zhang, Fang Hua, **nchun Ye, Wei Zhang, Liguo Dong, Shenyang Zhang, **aopeng Wang & Guiyun Cui

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  1. Hafiz Khuram Raza
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  2. Hao Chen
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Correspondence to Hao Chen or Guiyun Cui.

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Raza, H.K., Chen, H., Chansysouphanthong, T. et al. The clinical and imaging features of gray matter heterotopia: a clinical analysis on 15 patients. Neurol Sci 40, 489–494 (2019). https://doi.org/10.1007/s10072-018-3667-9

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  • DOI: https://doi.org/10.1007/s10072-018-3667-9

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