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Usefulness of nutraceuticals in migraine prophylaxis

  • SYMPOSIUM - NUTRACEUTICS AND HEADACHE
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Abstract

Several studies have supported the efficacy of complementary and alternative medicine approaches (physical, behavioral and nutraceutical therapies) in the treatment of headache disorders. Nutraceutical treatment consists of taking vitamins, supplements (magnesium, riboflavin, coenzyme Q10, and alpha lipoic acid) and herbal preparations (feverfew and butterbur), and its usage is frequently determined by dissatisfaction with conventional medical therapies. There is a growing body of research on nutraceutical use for migraine prophylaxis. This brief overview provides information about the potential efficacy and side effects of various nutraceutical products summarizing randomized controlled trials of some of the most commonly used non-pharmacological treatments for the prophylaxis and treatment of migraine, including magnesium, coenzyme Q10, riboflavin (vitamin B2), petasites, and feverfew.

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References

  1. Kalra EK (2003) Nutraceutical—definition and introduction. AAPS Pharm Sci 5:27–28

    Article  Google Scholar 

  2. Sun-Edelstein C, Mauskop A (2011) Alternative headache treatments: nutraceuticals, behavioral and physical treatments. Headache 51(3):469–483

    Article  PubMed  Google Scholar 

  3. Daniel O, Mauskop A (2016) Nutraceuticals in acute and prophylactic treatment of migraine. Curr Treat Options Neurol 18(4):14

    Article  PubMed  Google Scholar 

  4. Kandasamy AD (2014) Nutraceuticals for the treatment of migraine prophylaxis. Discov Phytomed 1:16–21

    Article  Google Scholar 

  5. D’Amico D, Tepper SJ (2008) Prophylaxis of migraine: general principles and patient acceptance. Neuropsychiatr Dis Treat 4(6):1155–1167

    Article  PubMed  PubMed Central  Google Scholar 

  6. Rybicka JM, Balce DR, Chaudhuri S, Allan ERO, Yates RM (2012) Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner. EMBO J 31(4):932–944

    Article  CAS  PubMed  Google Scholar 

  7. Gaul C, Diener HC, Danesch U; Migravent® Study Group (2015) Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial. J Headache Pain 16:516

  8. Mauskop A, Altura BT, Altura BM (2002) Serum ionized magnesium levels and serum ionized calcium/ionized magnesium ratios in women with menstrual migraine. Headache 42:242–248

    Article  PubMed  Google Scholar 

  9. Chiu HY, Yeh TH, Huang YC, Chen PY (2016) Effects of intravenous and oral magnesium on reducing migraine: a meta-analysis of randomized controlled trials. Pain Physician 19(1):E97–E112

    PubMed  Google Scholar 

  10. Teigen L, Boes CJ (2015) An evidence-based review of oral magnesium supplementation in the preventive treatment of migraine. Cephalalgia 35(10):912–922

    Article  PubMed  Google Scholar 

  11. Schoenen J, Jacquy J, Lenaerts M (1998) Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 50(2):466–470

    Article  CAS  PubMed  Google Scholar 

  12. Sandor PS, Afra J, Ambrosini A, Schoenen J (2000) Prophylactic treatment of migraine with beta-blockers and riboflavin: differential effects on the intensity dependence of auditory evoked cortical potentials. Headache 40:30–35

    Article  CAS  PubMed  Google Scholar 

  13. Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhäupl KM, Arnold G (2004) High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol 11(7):475–477

    Article  CAS  PubMed  Google Scholar 

  14. MacLennan SC, Wade FM, Forrest KM, Ratanayake PD, Fagan E, Antony J (2008) High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol 23(11):1300–1304

    Article  PubMed  Google Scholar 

  15. Grossmann M, Schmidramsl H (2000) An extract of Petasites hybridus is effective in the prophylaxis of migraine. Int J Clin Pharmacol Ther 38(9):430–435

    Article  CAS  PubMed  Google Scholar 

  16. Diener HC, Rahlfs VW, Danesch U (2004) The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria. Eur Neurol 51(2):89–97

    Article  CAS  PubMed  Google Scholar 

  17. Lipton RB, Göbel H, Einhäupl KM, Wilks K, Mauskop A (2004) Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology 63(12):2240–2244

    Article  CAS  PubMed  Google Scholar 

  18. Pothmann R, Danesch U (2005) Migraine prevention in children and adolescents: results of an open study with a special butterbur root extract. Headache 45(3):196–203

    Article  PubMed  Google Scholar 

  19. Utterback G, Zacharias R, Timraz S, Mershman D (2014) Butterbur extract: prophylactic treatment for childhood migraines. Complement Ther Clin Pract 20(1):61–64

    Article  PubMed  Google Scholar 

  20. Diener HC, Pfaffenrath V, Schnitker J, Friede M, Henneicke-von Zepelin HH (2005) Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention—a randomized, double-blind, multicentre, placebo-controlled study. Cephalalgia 25(11):1031–1041

    Article  CAS  PubMed  Google Scholar 

  21. Pittler MH, Ernst E (2004) Feverfew for preventing migraine. Cochrane Database Syst Rev 1:CD002286

    Google Scholar 

  22. Sandor PS, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D, Seidel L, Agosti RM, Schoenen J (2005) Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology 64(4):713–715

    Article  CAS  PubMed  Google Scholar 

  23. Rozen TD, Oshinsky ML, Gebeline CA, Bradley KC, Young WB, Shechter AL, Silberstein SD (2002) Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia 22(2):137–141

    Article  CAS  PubMed  Google Scholar 

  24. Shoeibi A, Olfati N, Soltani Sabi M, Salehi M, Mali S, Akbari Oryani M (2016) Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial. Acta Neurol Belg 117:103–109

    Article  PubMed  Google Scholar 

  25. Slater SK, Nelson TD, Kabbouche MA, LeCates SL, Horn P, Segers A, Manning P, Powers SW, Hershey AD (2011) A randomized, double-blinded, placebo-controlled, crossover, add-on study of CoEnzyme Q10 in the prevention of pediatric and adolescent migraine. Cephalalgia 31(8):897–905

    Article  PubMed  Google Scholar 

  26. Cady RK, Goldstein J, Nett R, Mitchell R, Beach ME, Browning R (2011) A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic™ M) in the treatment of migraine. Headache 51(7):1078–1086

    Article  PubMed  Google Scholar 

  27. D’Andrea G, Bussone G, Allais G, Aguggia M, D’Onofrio F, Maggio M, Moschiano F, Saracco MG, Terzi MG, Petretta V, Benedetto C (2009) Efficacy of Ginkgolide B in the prophylaxis of migraine with aura. Neurol Sci 1:S121–S124

    Article  Google Scholar 

  28. Orr SL, Friedman BW, Christie S, Minen MT, Bamford C, Kelley NE, Tepper D (2016) Management of adults with acute migraine in the emergency department: the American Headache Society evidence assessment of parenteral pharmacotherapies. Headache 56(6):911–940

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Institute of Neurology San G. Moscati Hospital, Avellino, Italy

    Florindo D’Onofrio & Daniele Spitaleri

  2. Department of Psychology, University of Campania Luigi Vanvitelli, Viale Ellittico 31, 81100, Caserta, Italy

    Simona Raimo

  3. San Francesco Hospital, Telese Terme, Benevento, Italy

    Gerardo Casucci

  4. C. Besta Neurological Institute and Foundation, Milan, Italy

    Gennaro Bussone

Authors
  1. Florindo D’Onofrio
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  2. Simona Raimo
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  3. Daniele Spitaleri
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  4. Gerardo Casucci
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  5. Gennaro Bussone
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Corresponding author

Correspondence to Simona Raimo.

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D’Onofrio, F., Raimo, S., Spitaleri, D. et al. Usefulness of nutraceuticals in migraine prophylaxis. Neurol Sci 38 (Suppl 1), 117–120 (2017). https://doi.org/10.1007/s10072-017-2901-1

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  • DOI: https://doi.org/10.1007/s10072-017-2901-1

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