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Granulated copper oxide nanocatalyst: a mild and efficient reusable catalyst for the one-pot synthesis of 4-amino-5-pyrimidinecarbonitriles under aqueous conditions

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Abstract

An efficient method for the synthesis of 4-amino-5-pyrimidinecarbonitriles by the three-component reaction of malononitrile, aldehydes, and N-unsubstituted amidines under aqueous conditions using CuO microspheres as catalyst is reported. The catalyst exhibited remarkable reusable activity.

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Acknowldgements

The authors are thankful to the Nuclear Science and Technology Research Institute for partial financial support.

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Authors and Affiliations

  1. Nuclear Fuel Cycle School, Nuclear Science and Technology Research Institute, End of North Karegar Ave., P.O. Box 1439951113, Tehran, Iran

    Seyed Javad Ahmadi & Sodeh Sadjadi

  2. Department of Energy Engineering, Sharif University of Technology, Azadi Ave., P.O. Box 113658639, Tehran, Iran

    Morteza Hosseinpour

Authors
  1. Seyed Javad Ahmadi
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  2. Sodeh Sadjadi
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  3. Morteza Hosseinpour
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Corresponding author

Correspondence to Sodeh Sadjadi.

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Ahmadi, S.J., Sadjadi, S. & Hosseinpour, M. Granulated copper oxide nanocatalyst: a mild and efficient reusable catalyst for the one-pot synthesis of 4-amino-5-pyrimidinecarbonitriles under aqueous conditions. Monatsh Chem 142, 1163–1168 (2011). https://doi.org/10.1007/s00706-011-0579-2

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  • DOI: https://doi.org/10.1007/s00706-011-0579-2

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