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Molecular evolution of dengue virus: a Bayesian approach using 1581 whole-genome sequences from January 1944 to July 2022

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A Correction to this article was published on 31 July 2023

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Abstract

Dengue is a viral disease transmitted by mosquitoes that has spread rapidly across all continents in recent years. There are four distinct but closely related serotypes of the virus that causes dengue (DENV-1, DENV-2, DENV-3, and DENV-4). In the present study, we evaluated temporal spreading and molecular evolution of dengue virus (DENV) serotypes. Bayesian coalescent analysis was performed to study viral evolution, and it was estimated that the most recent common ancestor of DENV-1 was present in 1884 in Southeast Asia, that of DENV-2 was present in 1723 in Europe, that of DENV-3 was present in 1921 in Southeast Asia, and that of DENV-4 was present in 1876 in Southeast Asia. DENV appears to have originated in Spain in approximately 1682, and it was disseminated in Asia and Oceania in approximately 1847. After this period, the virus was introduced into North America in approximately 1890. In South America, it was first disseminated to Ecuador in approximately 1897 and then to Brazil in approximately 1910. Dengue has had a significant impact on global health worldwide, and the present study provides an overview of the molecular evolution of DENV serotypes.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Value Management Office, Medical Manager at Hospital Moinhos de Vento, Porto Alegre, RS, Brazil

    Jonas Wolf & Arthur Pille

  2. Researcher at Hospital Moinhos de Vento, Porto Alegre, RS, Brazil

    Ana Paula de Souza & Raine Fogliati de Carli Schardosim

  3. Medical Manager, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil

    Juçara Gasparetto Maccari

  4. Chief Executive Officer at Hospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, Brazil

    Mohamed Parrini Mutlaq

  5. Chief Medical Officer, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil

    Luiz Antonio Nasi

Authors
  1. Jonas Wolf
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  2. Ana Paula de Souza
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  3. Raine Fogliati de Carli Schardosim
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  4. Arthur Pille
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Correspondence to Jonas Wolf.

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Communicated by Tim Skern

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The original online version of this article was revised: Name of author Raine Fogliati De Carli Schardosim and the affiliation of author Juçara Gasparetto Maccari was corrected.

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Wolf, J., de Souza, A.P., Schardosim, R.F.d. et al. Molecular evolution of dengue virus: a Bayesian approach using 1581 whole-genome sequences from January 1944 to July 2022. Arch Virol 168, 202 (2023). https://doi.org/10.1007/s00705-023-05833-3

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