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A sensitive method to determine dopamine in the presence of uric acid based on In2O3 nanosheet arrays grown on 3D graphene

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Abstract

A nonenzymatic voltammetric assay for dopamine (DA) was developed based on the combination of three-dimensional graphene (3D Gr) and indium oxide nanosheet arrays (In2O3 NSAs). 3D Gr was prepared by chemical vapor deposition (CVD), and In2O3 NSAs were grown on its surface by hydrothermal synthesis. The results show that 3D Gr maintains a good porous structure (200 μm), and the pore size of In2O3 NSAs is 0.50 μm. Differential pulse voltammetry (DPV) is mainly used to determine the electrochemical properties of In2O3 NSAs/3D Gr. It possesses a sensitivity of 2.69 μA·μM−1·cm−2 towards DA (5–60 μM) at 0.14 V, and the detection limit (LOD) is 0.10 μM (S/N = 3). The recoveries obtained for spiked samples in the real sample detection is 105 (± 8)%.

Schematic representation of DA sensitive detection by growing In2O3 nanosheets arrays on three-dimentional graphene modified ITO.

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Acknowledgments

This work is supported by the fundamental research foundation for University of Heilongjiang province (LGYC2018JQ012) and the foundation for selected overseas Chinese Scholar, Ministry of personal of Heilongjiang province (2018383).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin, 150040, People’s Republic of China

    **nrui Guo, Hongyan Yue, **n Gao, Hongtao Chen, Pengfei Wu, Teng Zhang & Zengze Wang

  2. Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China

    Shuo Huang

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  1. **nrui Guo
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  2. Hongyan Yue
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  3. Shuo Huang
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  5. Hongtao Chen
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  7. Teng Zhang
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Correspondence to Hongyan Yue.

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Guo, X., Yue, H., Huang, S. et al. A sensitive method to determine dopamine in the presence of uric acid based on In2O3 nanosheet arrays grown on 3D graphene. Microchim Acta 187, 218 (2020). https://doi.org/10.1007/s00604-020-4199-6

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