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A MXene of type Ti3C2Tx functionalized with copper nanoclusters for the fluorometric determination of glutathione

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Abstract

Luminescent copper nanoclusters (Cu NCs) are chosen to functionalize Ti3C2Tx MXene flakes to form a new kind of nanohybrid. It was applied to the determination of glutathione (GSH) via photoluminescence (PL). The Cu NCs and MXene flakes are in close contact, and the blue PL of the Cu NCs (with excitation/emission peaks at 380/425 nm) is quenched. The addition of GSH triggers the separation of the nanohybrid. This results in the recovery of PL. GSH also promotes the PL of Cu NCs via host-guest interactions. Thus, target recognition, corresponding signal output and further magnification are accomplished in a single step. Under optimum conditions, the nanohybrid can detect GSH in the 5.0 to 100 μM concentration range and with a 3.0 μM detection limit. The assay is very specific and shows high selectivity towards metal ions, small biomolecules, amino acids, and thiol containing molecules.

Luminescent copper nanoclusters are used to functionalize Ti3C2Tx MXene flakes, forming a nanohybrid, which is applied to detect glutathione. Target recognition, signal output and magnification are accomplished in a single step, resulting in high selectivity.

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (21804030), Natural Science Foundation of Guangdong Province (Grant No. 2018A030310420), Natural Science Foundation of Shenzhen University (Grant No. 2017004), Shenzhen Science and Technology Research Grant (Grant No. JCYJ20170818142354137).

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Author notes

  1. Yu-e Shi and Fei Han contributed equally to this work.

Authors and Affiliations

  1. College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, People’s Republic of China

    Yu-e Shi, Chuanchuan Zhang, Tianzi Li, Henggang Wang & Zhenguang Wang

  2. College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518055, China

    Fei Han, Luoyuan **e & Yang Huang

  3. Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China

    Fei Han

  4. Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, 11 Yuk Choi Rd, Hung Hom, Hong Kong

    Wing-Fu Lai

  5. School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006, China

    Shaojuan Luo

  6. Key Laboratory of Advanced Technologies of Materials (Ministry of Education) School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China

    Wei Wei

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  1. Yu-e Shi
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Correspondence to Zhenguang Wang or Yang Huang.

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Shi, Ye., Han, F., **e, L. et al. A MXene of type Ti3C2Tx functionalized with copper nanoclusters for the fluorometric determination of glutathione. Microchim Acta 187, 38 (2020). https://doi.org/10.1007/s00604-019-4000-x

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