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A porous polymeric–hydroxyapatite scaffold used for femur fractures treatment: fabrication, analysis, and simulation

  • Original Article • HIP - BIOMATERIALS
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European Journal of Orthopaedic Surgery & Traumatology Aims and scope Submit manuscript

Abstract

Background

One of the most common fractures in the skeleton happens in the femur. One of the important reasons for this fracture is because it is the longest bone in the body and osteoporosis affect this part a lot. The geometric complexity and anisotropy properties of this bone have received a lot of attention in the orthopedic field.

Methods

In this research, a femur designed using 3D printing machine using the middle part of the hip made of polylactic acid–hydroxyapatite (PLA–HA) nanocomposite containing 0, 5, 10, 15, and 25 wt% of ceramic nanoparticle. Three different types of loadings, including centralized loading, full-scale, and partially loaded, were applied to the designed femur bone. The finite element analysis was used to analyze biomechanical components.

Results

The results of the analysis showed that it is possible to use the porous scaffold model for replacement in the femur having proper strength and mechanical stability. Stress–strain analysis on femoral implant with biometric HA and PLA after modeling was performed using the finite element method under static conditions in Abaqus software.

Conclusion

Three scaffold structures, i.e., mono-, hybrid, and zonal structures, that can be fabricated using current bioprinting techniques are also discussed with respect to scaffold design.

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Acknowledgements

We acknowledge Amirkabir University Technology for their kind support throughout this research and proofreading the manuscript.

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Authors and Affiliations

  1. New Technologies Research Center, Amirkabir University of Technology, Tehran, 15875-4413, Iran

    Saeid Esmaeili, Saeed Saber-Samandari, Amir Hussein Montazeran & Amirsalar Khandan

  2. Department of Orthopedic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Hossein Akbari Aghdam & Mehdi Motififard

  3. Mechanical Engineering Department, Iran University of Science and Technology, Tehran, Iran

    Mohammad Bigonah

  4. Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Erfan Sheikhbahaei

Authors
  1. Saeid Esmaeili
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  2. Hossein Akbari Aghdam
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  4. Saeed Saber-Samandari
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  5. Amir Hussein Montazeran
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  8. Amirsalar Khandan
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Correspondence to Amirsalar Khandan.

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The authors declare no potential conflict of interests.

Ethical approval

This study started after receiving its scientific ethical approval from Isfahan University of Medical Sciences that registered inquiry and funding under the No. 198091 and IR.MUI.RESEARCH.REC.1398.218 (clinical research section).

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Esmaeili, S., Akbari Aghdam, H., Motififard, M. et al. A porous polymeric–hydroxyapatite scaffold used for femur fractures treatment: fabrication, analysis, and simulation. Eur J Orthop Surg Traumatol 30, 123–131 (2020). https://doi.org/10.1007/s00590-019-02530-3

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