SpringerLink
Log in

A 2-month-old infant with vomiting, seizures, and progressive apathy

  • Case Report
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

A 2-month-old infant was admitted to hospital because of recurrent vomiting for 1 week, progressive apathy, and focal seizures. The cranial MRI showed a noticeable result.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Alexander WS (1949) Progressive fibrinoid degeneration of fibrillary astrocytes associated with mental retardation in a hydrocephalic infant. Brain 72:373–381

    Article  PubMed  CAS  Google Scholar 

  2. Borett D, Becker LE (1985) Alexander´s disease: a disease of astrocytes. Brain 108(Pt 2):367–385

    Article  Google Scholar 

  3. Brenner M, Johnson AB, Boespflug-Tanguy O, Rodriguez D, Goldman JE, Messing A (2001) Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease. Nat Genet 27:117–120

    Article  PubMed  CAS  Google Scholar 

  4. Kyllerman M, Rosengren L, Wiklund LM, Hohmberg E (2005) Increased levels of GFAP in the cerebrospinal fluid in three subtypes of genetically confirmed Alexander disease. Neuropediatrics 36(5):319–323

    Article  PubMed  CAS  Google Scholar 

  5. van der Knaap MS, Naidu S, Breiter SN, Blaser S, Stroink H, Springer S, Begeer JC, van Coster R, Barth PG, Thomas NH, Valk J, Powers JM (2001) Alexander disease: diagnosis with MR imaging. Am J Neuroradiol 22:541–552

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of General Pediatrics and Neonatology, University Hospital of Saarland, Kirrbergerstr. Building 9, 66421, Homburg, Germany

    Alexander Larsen, Christine Martin, Sascha Meyer, Tilman Rohrer & Ludwig Gortner

  2. Department of Neuroradiology, University Hospital of Saarland, Homburg, Germany

    Panagiotis Papanagiotou

  3. Department of Child Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    Marjo van der Knaap

Authors
  1. Alexander Larsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christine Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sascha Meyer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tilman Rohrer
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Panagiotis Papanagiotou
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Marjo van der Knaap
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ludwig Gortner
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alexander Larsen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Larsen, A., Martin, C., Meyer, S. et al. A 2-month-old infant with vomiting, seizures, and progressive apathy. Eur J Pediatr 171, 993–995 (2012). https://doi.org/10.1007/s00431-012-1681-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00431-012-1681-0

Keywords

Search

Navigation