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Expression of the breast differentiation antigen NY-BR-1 in a phyllodes tumor of the vulva

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Abstract

We describe a phyllodes tumor of borderline malignancy in the labium majus of a 49-year-old woman. The histogenetic origin of phyllodes tumors in the vulva is controversial. Strong immunoreactivity for NY-BR-1, a novel breast differentiation antigen, was demonstrated within the epithelial components of the phyllodes tumor. A similar expression pattern was observed in mammary-like glands of the vulva. These findings provide further evidence that phyllodes tumors of the vulva might derive from mammary-like glands in the labium majus or from ectopic breast tissue.

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Authors and Affiliations

  1. Institute of Surgical Pathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091, Zurich, Switzerland

    Olivier T. Giger, Barbara Padberg, Holger Moch & Zsuzsanna Varga

  2. Department of Gynecology, Hospital Uster, Uster, Switzerland

    Elena Lacoste & Christoph Honegger

Authors
  1. Olivier T. Giger
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  2. Elena Lacoste
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  3. Christoph Honegger
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  4. Barbara Padberg
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  5. Holger Moch
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  6. Zsuzsanna Varga
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Correspondence to Olivier T. Giger.

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Giger, O.T., Lacoste, E., Honegger, C. et al. Expression of the breast differentiation antigen NY-BR-1 in a phyllodes tumor of the vulva. Virchows Arch 450, 471–474 (2007). https://doi.org/10.1007/s00428-007-0377-8

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  • DOI: https://doi.org/10.1007/s00428-007-0377-8

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