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A case of mucoepidermoid carcinoma with melanin pigmentation manifested in the palate

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Abstract

This paper describes the first documented case of mucoepidermoid carcinoma (MEC) with melanin pigmentation manifested in the palate. Histopathological sections showed a neoplasm composed of epidermoid, mucous-producing and intermediate cells. Numerous large cells contained dark pigmented materials. Fontana Masson staining revealed dendritic melanocytes and melanin granules. HMB-45, Melan A and S-100 protein were all positive for melanocytes. Histopathological examination was not typical for malignant melanoma; the lesion was diagnosed as a low-grade MEC with melanin pigmentation.

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Authors and Affiliations

  1. Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan

    Joji Sekine & Tsugio Inokuchi

  2. Division of Pathology, Nagasaki University Hospital, Nagasaki, Japan

    Masanobu Anami

  3. Division of Oral Pathology and Bone Metabolism, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

    Shuichi Fujita

  4. Institute of Pathology, Otto-von-Guericke Universität, Magdeburg, Germany

    Michael Vieth

Authors
  1. Joji Sekine
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  2. Masanobu Anami
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  3. Shuichi Fujita
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  4. Michael Vieth
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  5. Tsugio Inokuchi
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Corresponding author

Correspondence to Joji Sekine.

Additional information

M. Vieth received a research grant from the Japanese Society of Pathology at the Institute of Pathology, Shiga University of Medical Science, Ohtsu, Japan

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Sekine, J., Anami, M., Fujita, S. et al. A case of mucoepidermoid carcinoma with melanin pigmentation manifested in the palate. Virchows Arch 446, 460–462 (2005). https://doi.org/10.1007/s00428-005-1213-7

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  • DOI: https://doi.org/10.1007/s00428-005-1213-7

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