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Survival and prognostic factors of primary retroperitoneal sarcomas after surgery: a single-center experience

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Abstract

Purpose

The percentage of retroperitoneal sarcomas (RPS) among all soft tissue sarcomas ranges from 10 to 15%. Surgery remains the gold standard for RPS. In this study, we analyzed the impact of surgical treatment for primary RPS on recurrence and overall mortality at a Chinese institution and identified and evaluated prognostic variables.

Methods

Data from patients with RPS who underwent surgical treatment were retrospectively analyzed. The patients were treated at a single center from January 2000 to June 2018. Retrospectively collected demographic, clinicopathological, and surgical factors were examined. Overall survival (OS) and disease-free survival (DSF) were used as the primary endpoints. Predicted 5-year survival rates, encompassing both DFS and OS, were derived from the Sarculator prognostic nomogram.

Results

A total of 110 patients met the inclusion criteria. The median follow-up time after surgery for patients with primary RPS was 5.3 years. During this period, 59 patients died. The 5-year OS and DFS estimates were 63.5% and 35.3%, respectively. In a multivariate analysis, poor OS following surgical treatment of primary RPS was independently correlated with FNCLCC grade (p < 0.001) and surgical margin status (p = 0.016). FNCLCC grade (p = 0.001) and surgical margin status (p = 0.002) were also independently associated with poor DFS. The C-indices for 5-year OS and DFS survival utilizing the Sarculator prognostic nomogram were 0.71 and 0.73 respectively.

Conclusion

The overall mortality rate of patients with RPS was considered acceptable. OS and DFS prognostic markers were established for primary RPS. Tumor grade and intraregional margins are other factors that affect survival and recurrence.

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Data availability

No datasets were generated or analysed during the current study.

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Funding

This study was financially supported by National Natural Science Foundation of China (NO.82373014).

Author information

Author notes

  1. Shuai Zhao and Jiajie Zhou have contributed equally to this work.

Authors and Affiliations

  1. Clinical Teaching Hospital of Medical School, Northern Jiangsu People’s Hospital, Nan**g University, Yangzhou, China

    Shuai Zhao, Jiajie Zhou, Ruiqi Li & Daorong Wang

  2. Department of General Surgery, Taizhou Fourth People’s Hospital, Taizhou, China

    Longhe Sun

  3. Department of General Surgery, Northern Jiangsu People’s Hospital, Yangzhou, China

    Qiannan Sun, Wei Wang & Daorong Wang

  4. Yangzhou Key Laboratory of Basic and Clinical Transformation of Digestive and Metabolic Diseases, Yangzhou, China

    Qiannan Sun & Daorong Wang

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  1. Shuai Zhao
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Contributions

Conception/design: SZ, RL, JZ and DW. Manuscript writing: SZ, LS, JZ, RL, QS and WW. Final approval of manuscript: SZ, RL, JZ, LS, QS, WW and DW.

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Correspondence to Daorong Wang.

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Zhao, S., Zhou, J., Li, R. et al. Survival and prognostic factors of primary retroperitoneal sarcomas after surgery: a single-center experience. Langenbecks Arch Surg 409, 216 (2024). https://doi.org/10.1007/s00423-024-03405-w

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