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Correlation between pupillary size and depth of focus after the implantation of extended depth of focus intraocular lenses

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Abstract

Purpose

To evaluate whether depth of focus after the implantation of extended depth of focus (EDoF) intraocular lenses (IOLs) correlates with pupillary size.

Methods

This retrospective case series study evaluated eyes undergoing cataract surgery with implantation of EDoF IOLs. At least one month postoperatively, the depth of focus (DoF) was measured to determine the correlation with pupillary size, age, anterior chamber depth (ACD), axial length (AXL), and corneal spherical aberrations (SA).

Results

The study evaluated 64 eyes of 49 patients. The mean depth of focus was 2.67 diopters (D). The mean preoperative photopic pupil size was 3.36 mm. A significant negative association was found between preoperative photopic pupil size and depth of focus (r = 0.30, Pearson’s correlation coefficient) and between preoperative mesopic pupil size and depth of focus (r = 0.274, Pearson’s correlation coefficient).

Key messages

What is known:

  • • Optical and visual performance of a multifocal IOL likely depends on pupil size.

What is new:

  • • Smaller pupil size (including preoperative photopic, mesopic pupil size) had strong association with good post-operative depth of focus, with Extended Depth of Focus Intraocular Lenses.

  • • No significant correlation was observed between age, anterior chamber depth, axial length, corneal spherical aberra?tions, and depth of focus in the Extended Depth of Focus Intraocular Lenses.

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Data availability

The datasets generated during and/or analyzed in this study are not publicly available due to privacy regulations set by the Shanghai Eye Diseases Prevention & Treatment Center but are available but are available from the corresponding author on reasonable request.

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Acknowledgements

We thank the participants of the study.

Not applicable.

Funding

Shanghai Eye Diseases Prevention and Treatment Center Support, Grant/Award Number: 21LC01003; The Natural Science Foundation of Shanghai, Grant/Award Number: 18ZR1435600; A three-year action plan for TCM inheritance, innovation and development, Grant/Award Number: No.ZY (2021–2023)-0207-01-09; Technology innovation project of Shanghai Shenkang Hospital Development Center, Grant/Award Number: SHDC12018 × 16.

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Author notes

  1. **aoling Fang and Wenwen Xue are contributed equally to this work.

Authors and Affiliations

  1. Department of Ophthalmology, Shanghai Eye Diseases Prevention &Treatment Center/ Shanghai Eye Hospital, School of Medicine, Tongji University, National Clinical Research Center for Eye Diseases，Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, NO.1440 Hongqiao Road, Shanghai, 200336, China

    **aoling Fang, Wenwen Xue, Chunxia Yu, **hua Tao & Yulan Wang

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  1. **aoling Fang
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  2. Wenwen Xue
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Fang **aoling, Xue Wenwen, and Tao **hua]. The first draft of the manuscript was written by Fang **aoling and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yulan Wang.

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Ethical approval

The study was approved by the local ethics committee of the Shanghai Eye Diseases Prevention & Treatment Center(2021SQ015) and conducted according to the tenets of the Declaration of Helsinki. All patients provided written informed consent prior to inclusion to the study.

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The authors declare that they have no competing interests.

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**hua Tao and Yulan Wang are contributed equally to this work.

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Fang, X., Xue, W., Yu, C. et al. Correlation between pupillary size and depth of focus after the implantation of extended depth of focus intraocular lenses. Graefes Arch Clin Exp Ophthalmol (2024). https://doi.org/10.1007/s00417-024-06528-4

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