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Study on the correlation of C-reactive protein/albumin ratio with sudden sensorineural hearing loss complicated by hypertension: a prospective study

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Background

Understanding the pathophysiology of sudden sensorineural hearing loss (SSNHL) and identifying its clinical symptoms and associated risk factors are crucial for doctors in order to create effective prevention and therapeutic methods for this prevalent otolaryngologic emergency.

Methods

This study focuses on investigating the correlation between the C-reactive protein/albumin ratio (CAR) and SSNHL complicated by hypertension. In this study, 120 patients diagnosed with SSNHL were divided into groups with and without hypertension, and propensity score matching was used to compare and analyze the severity, type, prognosis, and CAR levels in SSNHL.

Results

The results showed that the SSNHL group with hypertension had significantly higher CAR levels, age, hearing curve abnormalities, and more severe hearing loss compared to the control group with isolated SSNHL. These differences were statistically significant (p < 0.001). Among different subtypes of SSNHL, CAR levels increased progressively with the advancement of the condition, and these differences were also statistically significant (p < 0.001).

Conclusion

In summary, in patients with SSNHL, those with hypertension had higher CAR levels than those without a history of hypertension, and they experienced more severe hearing loss. Moreover, there was a clear correlation between CAR levels and the extent of SSNHL, indicating that greater CAR levels in patients with SSNHL are connected to more severe hearing loss in various hearing patterns and perhaps indicative of a poorer prognosis.

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Data availability

The datasets generated and analyzed during the current investigation are available upon reasonable request from the corresponding author.

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Funding

This study was financially supported by the Jiangsu Province Natural Science Foundation (BK20201220).

Author information

Author notes

  1. Xu Zhang and Aijuan Cao have contributed equally to this work.

Authors and Affiliations

  1. Department of Otolaryngology, Head and Neck Surgery, Dalian Medical University, Dalian, 116000, China

    Xu Zhang & Yao Zhang

  2. Department of Otolaryngology, Dongtai Municipal People’s Hospital of Nantong University, No. 2 Kangfu West Road, Yancheng, 224200, Jiangsu, China

    Aijuan Cao

  3. Department of Digestive Medicine, Nanbu People’s Hospital, Nanchong, 637300, Sichuan, China

    Qiuling Dang

  4. Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230031, China

    Wentao Zhang

  5. Department of Otolaryngology, Head and Neck Surgery, The First People’s Hospital of Foshan, Hearing and Balance Medical Engineering Technology Center of Guangdong, Foshan, 528000, China

    Maohua Wang

  6. Department of Otolaryngology, Head and Neck Surgery, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China

    Bing Guan

  7. Department of Talent Work, Nan**g University of Posts and Telecommunications, Nan**g, 210000, China

    Enze Wu

  8. Department of Otolaryngology Head and Neck Surgery, Anhui No.2 Provincial People’s Hospital, Hefei, 230041, China

    Yunlong Hu

Authors
  1. Xu Zhang
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  2. Aijuan Cao
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  7. Bing Guan
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Contributions

The study’s concept and layout were proposed by Xu Zhang, Enze Wu and Yunlong Hu. The data collection and analysis were carried out by Xu Zhang, Aijuan Cao Qiuling Dang, Wentao Zhang and Yunlong Hu. The literature search was completed by Xu Zhang, Qiuling Dang, Yao Zhang, Maohua Wang and Bing Guan. The core manuscript was written by Xu Zhang, while editing and critical revision were carried out by Bing Guan, Enze Wu and Yunlong Hu. The study was managed by Bing Guan, Enze Wu and Yunlong Hu. The funding was obtained by Bing Guan and Yunlong Hu. The final draught of the paper has been approved by all authors once they have read it. The final manuscript was read and approved by all writers.

Corresponding authors

Correspondence to Enze Wu or Yunlong Hu.

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Conflict of interest

The authors have no competing interests to declare relevant to this article’s content.

Ethical approval

The study was approved by the Ethics Committee of the Ethics Review Committee of the Northern Jiangsu People’s Hospital Affiliated to Yangzhou University (Approval No. 2023ky138) and conducted according to the Declaration of Helsinki.

Informed consent

Informed consent was taken before each procedure from the patients.

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Zhang, X., Cao, A., Dang, Q. et al. Study on the correlation of C-reactive protein/albumin ratio with sudden sensorineural hearing loss complicated by hypertension: a prospective study. Eur Arch Otorhinolaryngol (2024). https://doi.org/10.1007/s00405-024-08684-z

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  • DOI: https://doi.org/10.1007/s00405-024-08684-z

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