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Global frequency and distribution of head and neck sarcomas in adulthood: a systematic review

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Abstract

Purpose

Head and neck sarcomas (HNS) constitute a rare and heterogeneous cancer entity. Management remains a challenge due their rarity and different biological behaviour among tens of subtypes. This systematic review aimed to describe HNS global frequency and distribution in adulthood.

Methods

A systematic review was performed using PICOTS search strategies for qualitative question and it was written in accordance with PRISMA 2020 Statement. 70,653 publications were identified, and 15 variables were evaluated for a total of 2428 patients.

Results

We identified 47 studies from 21 different countries from 5 different continents. Most of studies (83.3%) were performed in single institutions and America and Asia overruled for number of papers included (21 and 10, respectivelly). Osteosarcoma was more frequent, followed by chondrosarcoma, angiosarcoma and malignant fibrous histiocytoma. Early stage accounted for almost 80% of cases; advanced stage prevailed in develo** countries. 1783 patients (90.1%) underwent surgery and 780 (39.4%) had adjuvant therapy. 50.8% of patients experienced tumour recurrence and the lowest mortality rate was reported in Europe (29.9%).

Conclusions

HNS holds a relative poor prognosis possibly explained by the heterogeneity of the disease. Treatment of HNS has shown to be highly diverse among different countries, underlining the importance of uniformed treatment guidelines to achieve better patient management and to improve survival outcomes.

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References

  1. Cannon RB, Carpenter PS, Boothe D et al (2018) Academic facility utilization and survival outcomes in adult head and neck sarcomas: an NCDB analysis. Otolaryngol Head Neck Surg 159(3):473–483. https://doi.org/10.1177/0194599818768495

    Article  PubMed  Google Scholar 

  2. Peng KA, Grogan T, Wang MB (2014) Head and neck sarcomas: analysis of the SEER Database. Otolaryngol Head Neck Surg 151(4):627–633. https://doi.org/10.1177/0194599814545747

    Article  PubMed  PubMed Central  Google Scholar 

  3. Tran LM, Mark R, Meier R, Calcaterra TC, Parker RG (1992) Sarcomas of the head and neck. Progn Fact Treatment Strateg Cancer 70(1):169–177. https://doi.org/10.1002/1097-0142(19920701)70:1%3c169::aid-cncr2820700127%3e3.0.co;2-f

    Article  CAS  Google Scholar 

  4. Hui JYC (2016) Epidemiology and etiology of sarcomas. Surg Clin North Am 96(5):901–914. https://doi.org/10.1016/j.suc.2016.05.005

    Article  PubMed  Google Scholar 

  5. AK EN, JKC C, JR G, T T, PJ S. WHO classification of head and neck tumours. Vol 9. 5th ed. Accessed 18 Aug 2023. https://publications.iarc.fr/Book-And-Report-Series/Who-Classification-Of-Tumours/WHO-Classification-Of-Head-And-Neck-Tumours-2017

  6. Andersen S, Mann H, Krarup-Hansen A, Lajer CB, Grønhøj C (2019) Patient and tumour characteristics of adult head and neck soft tissue sarcomas: a systematic review and meta-analysis. Sarcoma 2019:1–8. https://doi.org/10.1155/2019/9725637

    Article  CAS  Google Scholar 

  7. Aljabab AS, Nason RW, Kazi R, Pathak KA (2011) Head and neck soft tissue sarcoma. Indian J Surg Oncol 2(4):286–290. https://doi.org/10.1007/s13193-012-0127-5

    Article  CAS  PubMed  Google Scholar 

  8. Farhood AI, Hajdu SI, Shiu MH, Strong EW (1990) Soft tissue sarcomas of the head and neck in adults. Am J Surg 160(4):365–369. https://doi.org/10.1016/S0002-9610(05)80544-6

    Article  CAS  PubMed  Google Scholar 

  9. Makary RF, Gopinath A, Markiewicz MR, Fernandes R (2017) Margin analysis: sarcoma of the head and neck. Oral Maxillofac Surg Clin North Am 29(3):355–366. https://doi.org/10.1016/j.coms.2017.04.002

    Article  PubMed  Google Scholar 

  10. Stiller CA, Trama A, Serraino D et al (2013) Descriptive epidemiology of sarcomas in Europe: report from the RARECARE project. Eur J Cancer 49(3):684–695. https://doi.org/10.1016/j.ejca.2012.09.011

    Article  CAS  PubMed  Google Scholar 

  11. Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71

    Article  PubMed  PubMed Central  Google Scholar 

  12. World Health Organization. International statistical classification of diseases and related health problems. World Health Organization; 2015. Accessed 18 Aug 2023. https://apps.who.int/iris/handle/10665/246208

  13. Study Quality Assessment Tools|NHLBI, NIH. Accessed 18 Aug 2023. https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools

  14. Allevi F, Fadda GL, Rosso C et al (2021) Diagnostic criteria for odontogenic sinusitis: a systematic review. Am J Rhinol Allergy 35(5):713–721. https://doi.org/10.1177/1945892420976766

    Article  PubMed  Google Scholar 

  15. Fadda GL, Allevi F, Rosso C et al (2021) Treatment of paranasal sinus fungus ball: a systematic review and meta-analysis. Ann Otol Rhinol Laryngol 130(11):1302–1310. https://doi.org/10.1177/00034894211002431

    Article  PubMed  Google Scholar 

  16. Martino B, Nitro L, De Pasquale L et al (2022) Conversion rates in robotic thyroid surgery: a systematic review and meta-analysis. Int J Med Robot 18(5):e2427. https://doi.org/10.1002/rcs.2427

    Article  PubMed  PubMed Central  Google Scholar 

  17. Cassoni A, Brauner E, Pucci R et al (2020) Head and neck osteosarcoma—the ongoing challenge about reconstruction and dental rehabilitation. Cancers (Basel) 12(7):1948. https://doi.org/10.3390/cancers12071948

    Article  PubMed  Google Scholar 

  18. Singh RP, Grimer RJ, Bhujel N, Carter SR, Tillman RM, Abudu A (2008) Adult head and neck soft tissue sarcomas: treatment and outcome. Sarcoma 2008:654987. https://doi.org/10.1155/2008/654987

    Article  PubMed  PubMed Central  Google Scholar 

  19. Zalaudek I, Gomez-Moyano E, Landi C et al (2013) Clinical, dermoscopic and histopathological features of spontaneous scalp or face and radiotherapy-induced angiosarcoma. Austral J Dermatol 54(3):201–207. https://doi.org/10.1111/j.1440-0960.2012.00943.x

    Article  Google Scholar 

  20. Piazza C, Del Bon F, Grazioli P et al (2014) Organ preservation surgery for low- and intermediate-grade laryngeal chondrosarcomas: analysis of 16 cases. Laryngoscope 124(4):907–912. https://doi.org/10.1002/lary.24416

    Article  PubMed  Google Scholar 

  21. Barosa J, Ribeiro J, Afonso L, Fernandes J, Monteiro E (2014) Head and neck sarcoma: analysis of 29 cases. Eur Ann Otorhinolaryngol Head Neck Dis 131(2):83–86. https://doi.org/10.1016/j.anorl.2012.11.007

    Article  CAS  PubMed  Google Scholar 

  22. Szablewski V, Neuville A, Terrier P et al (2015) Adult sinonasal soft tissue sarcoma: analysis of 48 cases from the French Sarcoma Group database. Laryngoscope 125(3):615–623. https://doi.org/10.1002/lary.24910

    Article  PubMed  Google Scholar 

  23. Andrä C, Rauch J, Li M et al (2015) Excellent local control and survival after postoperative or definitive radiation therapy for sarcomas of the head and neck. Radiat Oncol 10:140. https://doi.org/10.1186/s13014-015-0449-x

    Article  PubMed  PubMed Central  Google Scholar 

  24. Tardío JC, Pinedo F, Aramburu JA et al (2016) Pleomorphic dermal sarcoma: a more aggressive neoplasm than previously estimated. J Cutan Pathol 43(2):101–112. https://doi.org/10.1111/cup.12603

    Article  PubMed  Google Scholar 

  25. van Es RJ, Keus RB, van der Waal I, Koole R, Vermey A (1997) Osteosarcoma of the jaw bones Long-term follow up of 48 cases. Int J Oral Maxillofac Surg 26(3):191–197. https://doi.org/10.1016/s0901-5027(97)80818-1

    Article  PubMed  Google Scholar 

  26. Van Damme JP, Schmitz S, Machiels JP et al (2010) Prognostic factors and assessment of staging systems for head and neck soft tissue sarcomas in adults. Eur J Surg Oncol 36(7):684–690. https://doi.org/10.1016/j.ejso.2010.05.020

    Article  PubMed  Google Scholar 

  27. Zhang K, Qu P, Zhang E, Dai C, Shu Y, Chen B (2019) Primary temporal bone chondrosarcoma: experience with 10 cases. Acta Otolaryngol 139(10):837–842. https://doi.org/10.1080/00016489.2019.1641220

    Article  PubMed  Google Scholar 

  28. Amiruddin S, Yunus MRM, Baki MM (2017) A review of adult head and neck soft tissue sarcoma in a tertiary centre: Malaysia experience. Bangl J Med Sci 16(1):69–76. https://doi.org/10.3329/bjms.v16i1.31136

    Article  Google Scholar 

  29. Kobayashi K, Matsumoto F, Kodaira M et al (2016) Significance of delayed primary excision in localized nonmetastatic adult head and neck rhabdomyosarcoma. Cancer Med 5(10):2708–2714. https://doi.org/10.1002/cam4.855

    Article  PubMed  PubMed Central  Google Scholar 

  30. Zhang P, Zhao L, Zhu YJ et al (2017) Prognosis of fibrosarcoma in patients with and without a history of radiation for nasopharyngeal carcinoma. Ann Surg Oncol 24(2):434–440. https://doi.org/10.1245/s10434-016-5589-1

    Article  PubMed  Google Scholar 

  31. Ha SC, Oh JS, Roh JL et al (2017) Pretreatment tumor SUVmax predicts disease-specific and overall survival in patients with head and neck soft tissue sarcoma. Eur J Nucl Med Mol Imaging 44(1):33–40. https://doi.org/10.1007/s00259-016-3456-8

    Article  CAS  PubMed  Google Scholar 

  32. Cho YH, Kim JH, Khang SK, Lee JK, Kim CJ (2008) Chordomas and chondrosarcomas of the skull base: comparative analysis of clinical results in 30 patients. Neurosurg Rev 31(1):35–43. https://doi.org/10.1007/s10143-007-0099-z. (discussion 43)

    Article  PubMed  Google Scholar 

  33. Zeng Q, Tang PZ, Xu ZG, Qi YF, Wu XX, Liu WS (2009) Primary malignant fibrous histiocytoma of the thyroid. Eur J Surg Oncol 35(6):649–653. https://doi.org/10.1016/j.ejso.2008.09.001

    Article  CAS  PubMed  Google Scholar 

  34. Wang CP, Chang YL, Ting LL, Yang TL, Ko JY, Lou PJ (2009) Malignant fibrous histiocytoma of the sinonasal tract. Head Neck 31(1):85–93. https://doi.org/10.1002/hed.20936

    Article  CAS  PubMed  Google Scholar 

  35. Park SW, Kim HJ, Lee JH, Ko YH (2009) Malignant fibrous histiocytoma of the head and neck: CT and MR imaging findings. AJNR Am J Neuroradiol 30(1):71–76. https://doi.org/10.3174/ajnr.A1317

    Article  PubMed  PubMed Central  Google Scholar 

  36. Liu CY, Wang MC, Li WY, Chang SY, Chu PY (2006) Sarcoma of the larynx: treatment results and literature review. J Chin Med Assoc 69(3):120–124. https://doi.org/10.1016/S1726-4901(09)70189-3

    Article  PubMed  Google Scholar 

  37. Ohguri T, Imada H, Nomoto S et al (2005) Angiosarcoma of the scalp treated with curative radiotherapy plus recombinant interleukin-2 immunotherapy. Int J Radiat Oncol Biol Phys 61(5):1446–1453. https://doi.org/10.1016/j.ijrobp.2004.08.008

    Article  CAS  PubMed  Google Scholar 

  38. Chan JYW, Wong STS, Lau GISK, Wei WI (2012) Postradiation sarcoma after radiotherapy for nasopharyngeal carcinoma. Laryngoscope 122(12):2695–2699. https://doi.org/10.1002/lary.23282

    Article  PubMed  Google Scholar 

  39. Cai P, Wu Y, Li L et al (2013) CT and MRI of radiation-induced sarcomas of the head and neck following radiotherapy for nasopharyngeal carcinoma. Clin Radiol 68(7):683–689. https://doi.org/10.1016/j.crad.2013.01.004

    Article  PubMed  Google Scholar 

  40. Lim S, Lee S, Rha SY, Rho JK (2016) Cranofacial osteosarcoma: single institutional experience in Korea. Asia Pac J Clin Oncol 12(1):e149-153. https://doi.org/10.1111/ajco.12072

    Article  PubMed  Google Scholar 

  41. Miki Y, Tada T, Kamo R et al (2013) Single institutional experience of the treatment of angiosarcoma of the face and scalp. Br J Radiol 86(1030):20130439. https://doi.org/10.1259/bjr.20130439

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Hata M, Wada H, Ogino I et al (2014) Radiation therapy for angiosarcoma of the scalp: treatment outcomes of total scalp irradiation with X-rays and electrons. Strahlenther Onkol 190(10):899–904. https://doi.org/10.1007/s00066-014-0627-z

    Article  PubMed  Google Scholar 

  43. Chung J, Lee V, Tsang R et al (2015) Treatment outcomes of postradiation second head and neck malignancies managed by a multidisciplinary approach. Head Neck 37(6):815–822. https://doi.org/10.1002/hed.23674

    Article  PubMed  Google Scholar 

  44. Argon A, Doğanavşargıl B, Ünal Yıldırım F, Sezak M, Midilli R, Öztop F (2015) Osteosarcomas of jaw: experience of a single centre. J Plast Surg Hand Surg 49(1):13–18. https://doi.org/10.3109/2000656X.2014.909364

    Article  PubMed  Google Scholar 

  45. Park JT, Roh JL, Kim SO et al (2015) Prognostic factors and oncological outcomes of 122 head and neck soft tissue sarcoma patients treated at a single institution. Ann Surg Oncol 22(1):248–255. https://doi.org/10.1245/s10434-014-3870-8

    Article  PubMed  Google Scholar 

  46. Sumida T, Otawa N, Kamata YU et al (2015) A clinical investigation of oral sarcomas at multi-institutions over the past 30 years. Anticancer Res 35(8):4551–4555

    PubMed  Google Scholar 

  47. Ogawa K, Takahashi K, Asato Y et al (2012) Treatment and prognosis of angiosarcoma of the scalp and face: a retrospective analysis of 48 patients. Br J Radiol 85(1019):e1127-1133. https://doi.org/10.1259/bjr/31655219

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Shim T, Chillakuru Y, Darwish C et al (2021) Head and neck osteosarcomas: analysis of treatment trends and survival outcomes in the United States (2004–2016). Head Neck 43(11):3294–3305. https://doi.org/10.1002/hed.26817

    Article  PubMed  Google Scholar 

  49. Davis EC, Ballo MT, Luna MA et al (2009) Liposarcoma of the head and neck: the University of Texas M. D. Anderson Cancer Center experience. Head Neck 31(1):28–36. https://doi.org/10.1002/hed.20923

    Article  PubMed  Google Scholar 

  50. Trifiletti D, Amdur RJ, Dagan R et al (2012) Radiotherapy following gross total resection of adult soft tissue sarcoma of the head and neck. Pract Radiat Oncol 2(4):e121–e128. https://doi.org/10.1016/j.prro.2012.01.003

    Article  PubMed  Google Scholar 

  51. Givi B, Liu J, Bilsky M et al (2013) Outcome of resection of infratemporal fossa tumors. Head Neck 35(11):1567–1572. https://doi.org/10.1002/hed.23186

    Article  PubMed  Google Scholar 

  52. Patel TD, Vázquez A, Plitt MA, Baredes S, Eloy JA (2015) A case-control analysis of survival outcomes in sinonasal carcinosarcoma. Am J Otolaryngol 36(2):200–204. https://doi.org/10.1016/j.amjoto.2014.10.031

    Article  PubMed  Google Scholar 

  53. Barker JL, Paulino AC, Feeney S, McCulloch T, Hoffman H (2003) Locoregional treatment for adult soft tissue sarcomas of the head and neck: an institutional review. Cancer J 9(1):49–57. https://doi.org/10.1097/00130404-200301000-00009

    Article  PubMed  Google Scholar 

  54. Koch BB, Karnell LH, Hoffman HT et al (2000) National cancer database report on chondrosarcoma of the head and neck. Head Neck 22(4):408–425. https://doi.org/10.1002/1097-0347(200007)22:4%3c408::aid-hed15%3e3.0.co;2-h

    Article  CAS  PubMed  Google Scholar 

  55. Le QT, Fu KK, Kroll S et al (1997) Prognostic factors in adult soft-tissue sarcomas of the head and neck. Int J Radiat Oncol Biol Phys 37(5):975–984. https://doi.org/10.1016/s0360-3016(97)00103-x

    Article  CAS  PubMed  Google Scholar 

  56. Demicco EG, Deshpande V, Nielsen GP, Kattapuram SV, Rosenberg AE (2010) Well-differentiated osteosarcoma of the jaw bones: a clinicopathologic study of 15 cases. Am J Surg Pathol 34(11):1647–1655. https://doi.org/10.1097/PAS.0b013e3181f7dac6

    Article  PubMed  Google Scholar 

  57. Al-Daraji W, Lasota J, Foss R, Miettinen M (2009) Synovial sarcoma involving the head: analysis of 36 cases with predilection to the parotid and temporal regions. Am J Surg Pathol 33(10):1494–1503. https://doi.org/10.1097/PAS.0b013e3181aa913f

    Article  PubMed  Google Scholar 

  58. Köhler HF, Neves RI, Brechtbühl ER, Mattos Granja NV, Ikeda MK, Kowalski LP (2008) Cutaneous angiosarcoma of the head and neck: report of 23 cases from a single institution. Otolaryngol Head Neck Surg 139(4):519–524. https://doi.org/10.1016/j.otohns.2008.07.022

    Article  PubMed  Google Scholar 

  59. Domínguez-Malagón HR, González-Conde E, Cano-Valdez AM, Luna-Ortiz K, Mosqueda-Taylor A (2014) Expression of hormonal receptors in osteosarcomas of the jaw bones: clinico-pathological analysis of 21 cases. Med Oral Patol Oral Cir Bucal 19(1):e44-48. https://doi.org/10.4317/medoral.18729

    Article  PubMed  Google Scholar 

  60. Salcedo-Hernández RA, Lino-Silva LS, Luna-Ortiz K (2014) Maxillary sinus sarcomas: epidemiological and clinicopathological experience of 25 years in a National Reference Cancer Center. Indian J Otolaryngol Head Neck Surg 66(4):359–364. https://doi.org/10.1007/s12070-012-0522-9

    Article  PubMed  Google Scholar 

  61. González-González R, Bologna-Molina R, Molina-Frechero N, Domínguez-Malagon HR (2012) Prognostic factors and treatment strategies for adult head and neck soft tissue sarcoma. Int J Oral Maxillofac Surg 41(5):569–575. https://doi.org/10.1016/j.ijom.2012.02.002

    Article  PubMed  Google Scholar 

  62. Fasunla AJ, Daniel A (2013) Retrospective review of soft tissue sarcoma of head and neck in a West African hospital. Alex J Med 49(1):43–48. https://doi.org/10.4314/bafm.v49i1

    Article  Google Scholar 

  63. Hardison SA, Davis PL, Browne JD (2013) Malignant fibrous histiocytoma of the head and neck: a case series. Am J Otolaryngol 34(1):10–15. https://doi.org/10.1016/j.amjoto.2012.06.010

    Article  PubMed  Google Scholar 

  64. Toro JR, Travis LB, Wu HJ, Zhu K, Fletcher CDM, Devesa SS (2006) Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results program, 1978–2001: an analysis of 26,758 cases. Int J Cancer 119(12):2922–2930. https://doi.org/10.1002/ijc.22239

    Article  CAS  PubMed  Google Scholar 

  65. de Bree R, van der Waal I, de Bree E, Leemans CR (2010) Management of adult soft tissue sarcomas of the head and neck. Oral Oncol 46(11):786–790. https://doi.org/10.1016/j.oraloncology.2010.09.001

    Article  PubMed  Google Scholar 

  66. Karanian M, Coindre JM (2015) Fourth edition of WHO classification tumours of soft tissue. Ann Pathol 35(1):71–85. https://doi.org/10.1016/j.annpat.2014.11.003

    Article  PubMed  Google Scholar 

  67. Jo VY, Doyle LA (2016) Refinements in sarcoma classification in the current 2013 World Health Organization Classification of tumours of soft tissue and bone. Surg Oncol Clin N Am 25(4):621–643. https://doi.org/10.1016/j.soc.2016.05.001

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Young Confederation of European ORL-HNS, Y-CEORL-HNS, Vienna, Austria

    Giuditta Mannelli, Sara Bassani, Ginevra Cosi, Matteo Fermi, Luca Gazzini, Carlotta Liberale, Luca Mazzetti, Giampiero Parrinello, Alberto Maria Saibene, Gabriele Molteni & Lara Valentina Comini

  2. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

    Giuditta Mannelli, Ginevra Cosi & Luca Mazzetti

  3. Unit of Otorhinolaryngology, Head and Neck Department, University of Verona, Verona, Italy

    Sara Bassani & Carlotta Liberale

  4. Otolaryngology and Audiology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy

    Matteo Fermi & Gabriele Molteni

  5. Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, Bologna, Italy

    Matteo Fermi & Gabriele Molteni

  6. Department of Otolaryngology-Head and Neck Surgery, Hospital of Bolzano (SABES-ASDAA), Teaching Hospital of the Paracelsus Medical Private University (PMU), Bolzano, Italy

    Luca Gazzini

  7. Department of Otolaryngology-Head and Neck Surgery, IRCCS San Martino Polyclinc Hospital, Genoa, Italy

    Giampiero Parrinello

  8. Otolaryngology Department, Department of Health Sciences, Santi Paolo e Carlo Hospital, Università Degli Studi di Milano, Milan, Italy

    Alberto Maria Saibene

  9. Head and Neck Oncology, Candiolo Cancer Institute, FPO-IRCCS, Strada Provinciale, 142-KM 3.95, 10060, Candiolo, TO, Italy

    Lara Valentina Comini

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  1. Giuditta Mannelli
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Mannelli, G., Bassani, S., Cosi, G. et al. Global frequency and distribution of head and neck sarcomas in adulthood: a systematic review. Eur Arch Otorhinolaryngol 281, 2553–2567 (2024). https://doi.org/10.1007/s00405-024-08477-4

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