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Use of tranexamic acid in medial open wedge high tibial osteotomy

  • Arthroscopy and Sports Medicine
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A Correction to this article was published on 03 May 2023

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Abstract

Purpose

Aim of this study was to evaluate the effect of tranexamic acid (TXA) on the outcome after medial open wedge osteotomy.

Material and methods

A prospective non-randomized comparative study with 52 patients has been performed. In both treatment groups, the same surgical technique for the medial open wedge HTO was used. In group 1 (N: 26) the patients received 1 g TXA i.v. preoperatively, in group 2 (N: 26) no TXA was given. Primary outcome measure was the decrease in hemoglobin concentration. Secondary outcome criteria were postoperative pain, intraarticular effusion (measured by ultrasound), range of motion (ROM) at discharge, peri- and postoperative complications and the KOOS PS (pre- and postoperatively at 1 year follow up).

Results

Hemoglobin decrease was significantly less in the TXA group compared to the non TXA group. Postoperative pain and intraarticular effusion was also significantly lower and ROM at discharge was higher in the TXA group. There was no group difference in peri- and postoperative complications and the pre- and postoperatively KOOS PS.

Conclusions

The results of the present study show the systemic application of 1 g TXA reduces hemoglobin drop and postoperative morbidity (pain, intraarticular effusion, and ROM) after tibial open wedge HTO.

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Acknowledgements

We would like to thank Kerstin Hofschulz for her help.

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Author notes

  1. Wolf Petersen and Mats Bentzin have contributed equally to the present work.

Authors and Affiliations

  1. Klinik Für Orthopädie Und Unfallchirurgie, Martin Luther Hospital, Caspar-Theyß-Straße 27-31, Grunewald, 14193, Berlin, Germany

    Wolf Petersen, Mats Bentzin, Sebastian Bierke, Hi Un Park & Martin Häner

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  1. Wolf Petersen
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Correspondence to Wolf Petersen.

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Conflict of interest

Wolf Petersen received consultancy fees from Karl Store, and lecture fees from Stryker, Plasmaconcept, Geistlich, and OPED. Mats Bentzin, Martin Häner and Sebastian Bierke have no conflict of interest.

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Petersen, W., Bentzin, M., Bierke, S. et al. Use of tranexamic acid in medial open wedge high tibial osteotomy. Arch Orthop Trauma Surg 142, 2287–2293 (2022). https://doi.org/10.1007/s00402-021-04219-x

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