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References
Aavikko M, Li SP, Saarinen S, Alhopuro P, Kaasinen E, Morgunova E et al (2012) Loss of SUFU function in familial multiple meningioma. Am J Hum Genet 91:520–526. https://doi.org/10.1016/j.ajhg.2012.07.015
Baia GS, Caballero OL, Orr BA, Lal A, Ho JS, Cowdrey C et al (2012) Yes-associated protein 1 is activated and functions as an oncogene in meningiomas. Mol Cancer Res 10:904–913. https://doi.org/10.1158/1541-7786.MCR-12-0116
Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G et al (2013) Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet 45:285–289. https://doi.org/10.1038/ng.2526
Capper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D et al (2018) DNA methylation-based classification of central nervous system tumours. Nature 555:469–474. https://doi.org/10.1038/nature26000
Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K et al (2013) Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science 339:1077–1080. https://doi.org/10.1126/science.1233009
Levy D, Adamovich Y, Reuven N, Shaul Y (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell 29:350–361. https://doi.org/10.1016/j.molcel.2007.12.022
Liu-Chittenden Y, Huang B, Shim JS, Chen Q, Lee SJ, Anders RA et al (2012) Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP. Genes Dev 26:1300–1305. https://doi.org/10.1101/gad.192856.112
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (2016) WHO classification of tumours of the central nervous system. IARC, Lyon
Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC et al (2006) Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci USA 103:12405–12410. https://doi.org/10.1073/pnas.0605579103
Pajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwil F et al (2015) Molecular classification of ependymal tumors across all CNS compartments, histopathological grades, and age groups. Cancer Cell 27:728–743. https://doi.org/10.1016/j.ccell.2015.04.002
Parker M, Mohankumar KM, Punchihewa C, Weinlich R, Dalton JD, Li Y et al (2014) C11orf95-RELA fusions drive oncogenic NF-kappaB signalling in ependymoma. Nature 506:451–455. https://doi.org/10.1038/nature13109
Pathmanaban ON, Sadler KV, Kamaly-Asl ID, King AT, Rutherford SA, Hammerbeck-Ward C et al (2017) Association of genetic predisposition with solitary schwannoma or meningioma in children and young adults. JAMA Neurol 74:1123–1129. https://doi.org/10.1001/jamaneurol.2017.1406
Sahm F, Schrimpf D, Stichel D, Jones DTW, Hielscher T, Schefzyk S et al (2017) DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis. Lancet Oncol 18:682–694. https://doi.org/10.1016/S1470-2045(17)30155-9
Smith MJ, O'Sullivan J, Bhaskar SS, Hadfield KD, Poke G, Caird J et al (2013) Loss-of-function mutations in SMARCE1 cause an inherited disorder of multiple spinal meningiomas. Nat Genet 45:295–298. https://doi.org/10.1038/ng.2552
Stichel D, Schrimpf D, Casalini B, Meyer J, Wefers AK, Sievers P et al (2019) Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions. Acta Neuropathol. https://doi.org/10.1007/s00401-019-02039-3
Valouev A, Weng Z, Sweeney RT, Varma S, Le QT, Kong C et al (2014) Discovery of recurrent structural variants in nasopharyngeal carcinoma. Genome Res 24:300–309. https://doi.org/10.1101/gr.156224.113
Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (2002) Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol Cell Biol 22:7688–7700. https://doi.org/10.1128/mcb.22.21.7688-7700.2002
Zhang N, Bai H, David KK, Dong J, Zheng Y, Cai J et al (2010) The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell 19:27–38. https://doi.org/10.1016/j.devcel.2010.06.015
Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J et al (2007) Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 21:2747–2761. https://doi.org/10.1101/gad.1602907
Zhao B, Ye X, Yu J, Li L, Li W, Li S et al (2008) TEAD mediates YAP-dependent gene induction and growth control. Genes Dev 22:1962–1971. https://doi.org/10.1101/gad.1664408
Acknowledgements
We thank L. Dörner and H. Y. Nguyen for skillful technical assistance and the microarray unit of the DKFZ Genomics and Proteomics Core Facility for providing Illumina DNA methylation array-related services. This study was supported by the German Cancer Aid (70112956) and Else Kröner-Fresenius Stiftung (EKFS 2015_A60). FS is a fellow of the Else Kröner Excellence Program of the Else Kröner-Fresenius Stiftung (EKFS 2017_EKES.24).
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Sievers, P., Chiang, J., Schrimpf, D. et al. YAP1-fusions in pediatric NF2-wildtype meningioma. Acta Neuropathol 139, 215–218 (2020). https://doi.org/10.1007/s00401-019-02095-9
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DOI: https://doi.org/10.1007/s00401-019-02095-9