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Biomarker in der Rheumatologie

Biomarker und Bildgebung zur Diagnose und Stratifizierung der rheumatoiden Arthritis und Spondylarthritis im BMBF-Verbund ArthroMark

Biomarkers in rheumatology

Biomarkers and imaging for the diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the ArthroMark network funded by the Federal Ministry of Education and Research

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Zusammenfassung

Seit Einführung der Biologika sind Biomarker zur Frühdiagnostik und Therapieentscheidung von zunehmender Bedeutung. Sie sollen im BMBF-geförderten Forschungsverbund ArthroMark für die rheumatoide Arthritis und die Spondylarthritis etabliert werden. Biobanken und Vorarbeiten zu Genotypen, Genexpressions- und Autoantigenprofilen dienen als Grundlage. Bioinformatische Vernetzung soll die Untersuchungen aufeinander abstimmen und eine Studie mit modernen Bildgebungsverfahren die funktionelle Bedeutung der neuen Biomarker bestmöglich charakterisieren. Zur Validierung der diagnostischen Marker wird eine schrittweise Erweiterung des Netzwerkes angestrebt.

Abstract

The introduction of biologics has continuously increased the demand for biomarkers for early diagnosis and therapeutic stratification. ArthroMark, a research network funded by the Federal Ministry of Education and Research, aims to establish such biomarkers for rheumatoid arthritis and spondyloarthritides. Biobanks and previous work on genoty**, gene expression and autoreactivity profiling build the basis. Bioinformatic networks will help to harmonize the investigations and a clinical study with modern imaging techniques to characterize the functional relevance of the new biomarkers as effectively as possible. To validate the markers for diagnostic application the network aims to expand gradually.

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Authors and Affiliations

  1. Medizinische Klinik m.S. Rheumatologie und Klinische Immunologie, Charité-Universitätsmedizin Berlin, Campus Mitte (CCM), Charitéplatz 1, 10117, Berlin, Deutschland

    T. Häupl, K. Skriner, T. Sörensen, B. Stuhlmüller & G.-R. Burmester

  2. Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin (CBF), Berlin, Deutschland

    H. Appel, M. Backhaus, M. Rudwaleit & J. Sieper

  3. Abteilung für Rheumatologie, Johann-Wolfgang-Goethe-Universität, Frankfurt, Deutschland

    H. Burkhardt

  4. Rheumaeinheit, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München, München, Deutschland

    M. Grünke, A. Skapenko & H. Schulze-Koops

  5. Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Deutschland

    A. Grützkau, J Listing & A. Zink

  6. Zentralinstitut für Laboratoriumsmedizin und Pathobiochemie, Charité, Berlin, Deutschland

    B. Hoppe

  7. Klinik für Endokrinologie, Diabetologie und Rheumatologie, Rheumazentrum Rhein-Ruhr, Heinrich-Heine-Universität, Düsseldorf, Deutschland

    B. Ostendorf

Authors
  1. T. Häupl
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  2. H. Appel
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  3. M. Backhaus
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  4. H. Burkhardt
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  5. M. Grünke
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  6. A. Grützkau
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  7. B. Hoppe
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  8. J Listing
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  9. B. Ostendorf
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  10. M. Rudwaleit
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  11. J. Sieper
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  12. A. Skapenko
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  13. K. Skriner
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  14. T. Sörensen
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  15. B. Stuhlmüller
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  16. A. Zink
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  17. H. Schulze-Koops
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  18. G.-R. Burmester
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Corresponding author

Correspondence to T. Häupl.

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Häupl, T., Appel, H., Backhaus, M. et al. Biomarker in der Rheumatologie. Z. Rheumatol. 71, 314–318 (2012). https://doi.org/10.1007/s00393-011-0781-y

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  • DOI: https://doi.org/10.1007/s00393-011-0781-y

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