Abstract
Background
Endoscopic callosotomy has emerged as a promising and minimally invasive technique for the treatment of refractory epilepsy. This paper aims to review the clinical outcomes and advancements associated with endoscopic callosotomy as a therapeutic option.
Materials and methods
This study includes 14 Paediatric patients diagnosed and managed at Al-azhar university hospitals. Those 14 patients were studied over 2 years. All patients underwent a corpus callosotomy using the bimanual endoscopic technique.
Results
Endoscopic anterior corpus callosotomy was done in 13 patients while one case underwent endoscopic complete callosotomy. The most frequent complication was transient disconnection syndrome followed by transient Urinary incontinence and one case had minor CSF leak. As regard seizure freedom outcome (Engel’s Outcome Scale): 4 cases (28.6%) became seizure free (Engle class I), 5 cases (35.7%) with Engle class II, 1 case (7.1%) with Engle class III and 4 cases (28.6%) classify as Engle class IV.
Conclusion
As a minimally invasive technique with a favorable impact on cognitive function, less complications and a significant reduction in seizure frequency and severity in the majority of paediatric patients, endoscopic corpus callosotomy offeres substantial benefits in managing refractory epilepsy in paediatric.
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Data availability
No datasets were generated or analysed during the current study.
Abbreviations
- AEDs:
-
Anti-epileptic drugs
- MRI:
-
Magnetic resonance imaging
- CT:
-
Computed tomography
- EEG:
-
Electroencephalography
- CSF:
-
Cerebrospinal fluid
References
Smith JM et al (2018) Minimally invasive callosotomy: a systematic review and meta-analysis. Epilepsia 59(10):1895–1907
Park EH et al (2019) Endoscopic corpus callosotomy: systematic review and meta-analysis. World Neurosurg 122:547–555
Tandon N et al (2020) Endoscopic corpus callosotomy: an emerging surgical technique. J Neurosurg 132(1):22–30
Sood S et al (2015) Endoscopic corpus callosotomy and hemispherotomy. J Neurosurgery: Pediatr 16(6):681–686
Sood S et al (2016) Endoscopic posterior interhemispheric complete corpus callosotomy. J Neurosurgery: Pediatr 18(6):689–692
Bahuleyan B et al (2012) Endoscopic total corpus callosotomy: cadaveric demonstration of a new approach. Pediatr NeuroSurg 47(6):455–460
Bahuleyan B et al (2010) Minimally invasive endoscopic transventricular hemispherotomy for medically intractable epilepsy: a new approach and cadaveric demonstration. J Neurosurgery: Pediatr 6(6):536–540
Patel NV et al (2019) Endoscopic corpus callosotomy for drug-resistant epilepsy: a systematic review. J Neurosurg 131(6):1832–1842
Shahwan A et al (2021) Long-term outcome following endoscopic corpus callosotomy: a systematic review and meta-analysis. Epileptic Disord 23(1):41–49
Liang S et al (2020) Endoscopic corpus callosotomy for drug-resistant epilepsy: a retrospective analysis of 30 cases. Seizure 83:48–53
Ng YS et al (2021) Endoscopic corpus callosotomy for pediatric drug-resistant epilepsy: a systematic review. Childs Nerv Syst 37(5):1433–1442
Van Gompel JJ et al (2020) Endoscopic corpus callosotomy: technical note and comparison with the open approach. World Neurosurg 138:337–342
Serino D et al (2018) Endoscopic corpus callosotomy: anatomic and technical aspects. Neurosurgery 82(1):23–31
Yin S et al (2020) Minimally invasive endoscopic callosotomy: preliminary clinical experience. J Neurosurg 134(5):1494–1501
Asadi-Pooya AA et al (2021) Short-term surgical outcomes and complications of endoscopic corpus callosotomy: a systematic review. J Neurosurg 135(5):1563–1569
Jayakar P et al (2021) Endoscopic corpus callosotomy: cognitive outcomes in pediatric patients. J Neurosurg Pediatr 27(2):137–145
Meador KJ et al (2017) Cognitive outcomes after epilepsy surgery: systematic review and pooled estimates. Epilepsia 58(6):974–982
Bajwa S et al (2019) Cognitive outcomes after corpus callosotomy: a systematic review. Epilepsy Res 153:30–37
Lee ST et al (2020) Predictors of favorable surgical outcome in endoscopic corpus callosotomy for drug-resistant epilepsy. J Neurosurg 134(4):1272–1281
Sharma M et al (2020) Endoscopic corpus callosotomy: long-term seizure and cognitive outcomes. Epilepsy Behav 112:107400
Park EH et al (2021) Comparative analysis of outcomes and complications between endoscopic and open corpus callosotomy: a systematic review and meta-analysis. Neurosurgery 88(1):97–109
Choi EK et al (2020) Comparative analysis of surgical outcomes and complications between open and endoscopic corpus callosotomy. Neurosurgery 87(1):167–176
Rosenow F et al (2013) Surgery for drug-resistant epilepsy: a consensus statement on its evaluation and outcome assessment. Epilepsia 54(Suppl 9):1–12
Englot DJ et al (2012) Epilepsy surgery trends in the United States, 1990–2008. Neurology 78(16):1200–1206
Mathieu F et al (2016) Surgery for epilepsy in the 21st century. World Neurosurg 88:619–621
Asadi-Pooya AA et al (2022) Endoscopic corpus callosotomy: is it ready for prime time? Epileptic Disord 24(2):125–128
Hammouda MR, Mohammed et al (2023) Outcome of epilepsy surgery in pediatrics. Al-Azhar Int Med J 4(6):1
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Islam Abdelfattah: collected the data and did the statistics and edited the manuscript mohamed hasan: the mead author and investigator who performed the surgery and supervised the editing steps.
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Supplementary Material 1
: Chart 1: A. post-operative complications of our case series. B. Engel’s Outcome Scale of our case series.
Supplementary Material 2
: Video 1: Intra-operative video showing Endoscopic anterior corpus callosotomy in one of our patients.
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Abdelsamad, I., Hasan, M. Endoscopic callosotomy as a minimally invasive approach to treat paediatric refractory epilepsy: case series. Childs Nerv Syst 40, 1807–1811 (2024). https://doi.org/10.1007/s00381-024-06319-6
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DOI: https://doi.org/10.1007/s00381-024-06319-6