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Clinical features, future cardiac events, and prognostic factors following percutaneous coronary intervention in young female patients

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Abstract

Background

The proportion of young females among the patients who undergo percutaneous coronary intervention (PCI) is relatively small, and information on their clinical characteristics is limited. This study investigated the clinical characteristics and prognostic factors for future cardiac events in young females who underwent PCI.

Methods

This multicenter observational study included 187 consecutive female patients aged < 60 years who underwent PCI in seven hospitals. The primary composite endpoint was the incidence of cardiac death, nonfatal myocardial infarction, and target vessel revascularization.

Results

The mean patient age was 52.1 ± 6.1 years and 89 (47.6%) had diabetes, and renal dysfunction (an estimated glomerular filtration rate < 60 mL/min/1.73 m2) was observed in 38 (20.3%). During a median follow-up of 3.3 years, the primary endpoint occurred in 28 patients. The Cox proportional hazards models showed that renal dysfunction was an independent predictor for the primary endpoint (hazard ratio 3.04, 95% confidence interval 1.25–7.40, p = 0.01), as well as multivessel disease (hazard ratio 2.79, 95% confidence interval 1.12–6.93, p = 0.03). Patients with renal dysfunction had a significantly higher risk for the primary endpoint than those without renal dysfunction.

Conclusions

Renal dysfunction was strongly associated with future cardiac events in young females who underwent PCI.

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Authors and Affiliations

  1. Department of Cardiology, Toyota Kosei Hospital, Toyota, Japan

    Yosuke Tatami, Taiki Ohashi, Ryuji Kubota, Shinji Kaneko & Masanori Shinoda

  2. Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, 466-8560, Japan

    Yosuke Tatami, Akihito Tanaka, Hiroshi Tashiro, Naoki Shibata, Naoki Yoshioka, Hideki Ishii & Toyoaki Murohara

  3. Cardiovascular Center, Anjo Kosei Hospital, Anjo, Japan

    Yusuke Uemura & Masato Watarai

  4. Department of Cardiology, Ogaki Municipal Hospital, Ogaki, Japan

    Kensuke Takagi, Naoki Shibata, Naoki Yoshioka & Itsuro Morishima

  5. Department of Cardiology, Konan Kosei Hospital, Konan, Japan

    Miho Tanaka & Yasunobu Takada

  6. Department of Cardiology, Ichinomiya Municipal Hospital, Ichinomiya, Japan

    Norio Umemoto, Hiroshi Tashiro & Kiyokazu Shimizu

  7. Department of Cardiology, Gunma University Graduate School of Medicine, Maebashi, Japan

    Hideki Ishii

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  1. Yosuke Tatami
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Correspondence to Akihito Tanaka.

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Conflict of interest

H.I. received lecture fees from Astellas Pharma Inc. Daiichi-Sankyo Pharma Inc. and MSD K.K. T. M. received lecture fees from BayerPharmaceutical Co., Ltd., Daiichi Sankyo Co., Ltd., Dainippon Sumitomo Pharma Co., Ltd., Kowa Co., Ltd., MSD K.K., Mitsubishi Tanabe Pharma Co., Nippon Boehringer Ingelheim Co., Ltd., Novartis Pharma K.K., Pfizer Japan Inc., Sanofi-aventis K.K., and Takeda Pharmaceutical Co., Ltd. T.M.received unrestricted research grant for Department of Cardiology, Nagoya University Graduate School of Medicine from Astellas Pharma Inc, Daiichi Sankyo Co., Ltd., Dainippon Sumitomo Pharma Co., Ltd., Kowa Co., Ltd., MSD K.K., Mitsubishi Tanabe Pharma Co., Nippon Boehringer Ingelheim Co., Ltd., Novartis Pharma K.K., Otsuka Pharma Ltd., Pfizer Japan Inc., Sanofi-aventis K.K., Takeda Pharmaceutical Co., Ltd., Tei** Pharma Ltd.

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Tatami, Y., Tanaka, A., Ohashi, T. et al. Clinical features, future cardiac events, and prognostic factors following percutaneous coronary intervention in young female patients. Heart Vessels 39, 505–513 (2024). https://doi.org/10.1007/s00380-024-02369-7

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