Abstract
Purpose: To analyze whether, in addition to survival, and disease-free survival progression-free interval after transplantation would be longer than the last progression-free interval before transplantation, supporting the argument that high-dose therapy may change the biologic behavior of the disease.
Patients and methods: Patients with a poor-risk relapsed follicular NHL were treated with three cycles of doxorubicin 50 mg/m2 and teniposide 60 mg/m2, followed by etoposide 350 mg/m2, cyclophosphamide 60 mg/kg, and TBI and unpurged BMT.
Results: Twelve patients were entered in the study. Ten patients fulfilled the criteria for response and underwent transplantation, two of them with an allograft. Nine of ten patients with transplants achieved a complete remission after BMT. One patient died on day 41 due to veno-occlusive disease. The nine patients with transplants who were evaluable for follow-up had a conversion of remission or response duration after transplantation, their progression-free interval after BMT being superior to the last one before BMT with a median of 1044+ days. Overall survival and disease-free survival in the transplant patients after a median follow-up of 1160 days from BMT is 90%.
Conclusion: High dose chemotherapy followed by stem cell rescue may change the clinical course in follicular non-Hodgkin's lymphoma patients.
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Received: 20 August 1996 / Accepted: 25 September 1996
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Schouten, H., Raemaekers, J., Kluin-Nelemans, J. et al. High-dose therapy followed by bone marrow transplantation for relapsed follicular non-hodgkin's lymphoma. Ann Hematol 73, 273–277 (1996). https://doi.org/10.1007/s002770050240
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DOI: https://doi.org/10.1007/s002770050240