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Triphasic dynamic CT findings of 63 hepatic focal nodular hyperplasia in 46 patients: correlation with size and pathological findings

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Abstract

Background

To correlate the dynamic computed tomography (CT) of hepatic focal nodular hyperplasia (FNH) with its size and pathology.

Methods

The clinical data, pathological and dynamic CT findings of 36 FNHs in 24 males and 27 lesions in 22 females were reviewed. The pathological and CT findings of the 32 small FNHs (diameter < 3 cm) and 31 large FNHs (diameter ≥ 3 cm) were compared and analyzed.

Results

All FNHs were hypervascular at arterial phase except for central scarring. The mean diameter of FNHs with hypoattenuating, isoattenuating, hyperattenuating on delayed scans were 5.05 cm, 3.06 cm, and 2.70 cm, respectively (p = 0.026). As compared with small FNHs, large ones were significantly more likely to reveal central scarring (p = 0.005), vascular displacement (p < 0.001), and abnormal vessels around lesions (p < 0001). Coexistent bile ductile proliferation and bridging septa were more commonly observed in small FNHs (p = 0.028 for both). FNHs without aberrant vessels tended to feature hyperattenuating during the portal venous phase (p = 0.041).

Conclusions

FNHs with different tumor sizes may manifest various dynamic CT findings that are more or less related to the different pathological findings.

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Authors and Affiliations

  1. Department of Radiology, Cardinal Tien Hospital, Yung Ho Branch, Yungho City, Taiwan

    Michael Che-Hung Lin

  2. Department of Public Health and Center of Biostatistics, Chang Gung University, Taoyuan, Taiwan

    Pei-Kwei Tsay

  3. Department of Radiology, Chang Gung Memorial Hospital at Kaohsiung, Chang Gung University, Taoyuan, Taiwan

    Sheung-Fat Ko

  4. Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Chang Gung University, 5 Fu-Hsing Road, Taoyuan, Taiwan

    Kar-Wai Lui, Jeng-Hwei Tseng, Chien-Fu Hung & Yung-Liang Wan

  5. Department of Pathology, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan

    Chuen Hsueh

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  1. Michael Che-Hung Lin
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  2. Pei-Kwei Tsay
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  3. Sheung-Fat Ko
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  4. Kar-Wai Lui
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  6. Chien-Fu Hung
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  8. Yung-Liang Wan
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Correspondence to Yung-Liang Wan.

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Lin, M.CH., Tsay, PK., Ko, SF. et al. Triphasic dynamic CT findings of 63 hepatic focal nodular hyperplasia in 46 patients: correlation with size and pathological findings. Abdom Imaging 33, 301–307 (2008). https://doi.org/10.1007/s00261-007-9258-5

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  • DOI: https://doi.org/10.1007/s00261-007-9258-5

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