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Associations between new obesity indices and abnormal bone density in type 2 diabetes mellitus patients

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Abstract

Summary

The clinical data analysis found that, compared with the traditional obesity index, the waist-weight ratio (WWR) has more advantages in predicting abnormal bone mineral density in subjects with type 2 diabetes. WWR may serve as a new predictive indicator for osteoporosis in T2DM patients.

Purpose

This study was designed to explore the correlation between obesity-related indices and bone mineral density (BMD) and its influencing factors in type 2 diabetes mellitus (T2DM) patients.

Methods

A total of 528 patients with type 2 diabetes were recruited. Glucose tolerance, insulin stimulation, and blood biochemical tests were conducted on all participants. All subjects underwent dual-energy X-ray bone density testing and were grouped based on the bone density results.

Results

Compared with those in the normal BMD group, the waist-to-body weight ratio (WWR) and weight-adjusted-waist index (WWI) in the osteopenia and osteoporosis groups were significantly greater, while body mass index (BMI) was significantly lower (P < 0.05). The logistic regression results showed that the WWR, WWI, and BMI were independently correlated with abnormal BMD in T2DM patients (P < 0.05). WWR and the WWI were negatively correlated with the T-value of bone density in various parts of the body, while BMI was positively correlated with the T-value of bone density (P < 0.05). The area under the working characteristic curve (AUC) for T2DM patients with abnormal bone mass predicted by the WWR [0.806, 95% CI = (0.770–0.843), P < 0.001] was greater than that for patients with other obesity indicators, such as the WWI and BMI.

Conclusion

We found a positive correlation between the WWR and bone density in T2DM patients. Compared with other obesity indicators, such as BMI and WWI, the WWR has a stronger discriminative ability for T2DM patients with abnormal bone density. Therefore, more attention should be given to the WWR in T2DM patients.

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Data availability

The data that support the findings of this study are available on request from the corresponding author.

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Acknowledgements

The authors sincerely thank all participants in this study.

Funding

This work was supported by the National Natural Science Foundation of China (82300903), the Key R&D Plan Social Development Project of Jiangsu Province (SBE2023741128, BE2018692), the National Natural Science Foundation of Jiangsu Province (SBK2023022865), the sixth phase 333 s level talent training project of Jiangsu Province (tackling bottleneck technology)(BRA2022008), the Projects from Social Development of Zhenjiang (SH2023029), the Affiliated Hospital of Jiangsu University Beigu Talent Cultivation Plan Project (BGYCB202206), and the Affiliated Hospital of Jiangsu University Doctoral Initiation Fund Project.

National Natural Science Foundation of China, 82300903, **a Deng, Key R&D Plan Social Development Project of Jiangsu Province, SBE2023741128, Guoyue Yuan, Natural Science Foundation of Jiangsu Province,SBK2023022865,Guoyue Yuan, sixth phase 333 s level talent training project of Jiangsu Province,BRA2022008,Guoyue Yuan, Projects from Social Development of Zhenjiang,SH2023029, **a Deng, Affiliated Hospital of Jiangsu University Beigu Talent Cultivation Plan Project, BGYCB202206, 邓霞 邓霞, Affiliated Hospital of Jiangsu University Doctoral Initiation Fund Project, jdfyRC2021005, **a Deng

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Author notes

  1. **a Deng, Xunan Wu, and Ziyan Sun contributed equally to this work.

Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, China

    **a Deng, Xunan Wu, Ziyan Sun, Qiaoyan Liu & Guoyue Yuan

  2. Endocrine Research Institute, The affiliated hospital of jiangsu university, Zhenjiang, China

    Guoyue Yuan

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  1. **a Deng
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Correspondence to Guoyue Yuan.

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This research complies with the principle of the Helsinki Declaration. All procedures performed in studies involving human participants were authorized by the Jiangsu University Affiliated Hospital Ethics Committee and its later amendments or comparable ethical standards.

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Deng, X., Wu, X., Sun, Z. et al. Associations between new obesity indices and abnormal bone density in type 2 diabetes mellitus patients. Osteoporos Int (2024). https://doi.org/10.1007/s00198-024-07163-9

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