Abstract
Purpose
The purpose of this study was to investigate the feasibility and effectiveness of high-dose planned adaptive intensity-modulated radiation therapy (IMRT) with helical tomotherapy (HT) for cutaneous angiosarcoma (cAS) of the scalp.
Methods
This retrospective cross-sectional included a total of 12 consecutive patients with cAS of the scalp who underwent high-dose planned adaptive IMRT with HT. Prescribed doses were 72.5–74 Gy in 35–37 fractions for the gross tumor volume plus a 1–2 mm margin (PTV1), 58–60 Gy in 29–30 fractions for the clinical target volume plus a 2–3 mm margin (PTV2), and 46 Gy in 23 fractions for the clinical target volume plus a 5–15 mm margin (PTV3) over periods of 7.5, 6 and 4.5 weeks, respectively.
Results
The estimated 1‑year and 2‑year overall survival rate were 65.6% and 27.3%, respectively, and the local progression-free survival at 2 years was 74.1%. All local recurrences were either in or marginal to the PTV2 or PTV3. No local recurrence was observed in the PTV1. All patients tolerated the treatment without grade 3 or higher adverse events during the radiotherapy period. No late adverse events were observed during the follow-up period.
Conclusion
Planned adaptive high-dose IMRT with HT has the potential to improve local control rate without increasing adverse events.
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Contributions
All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Yukihiro Hama, Toshiro Tsukamoto and Etsuko Tate. The first draft of the manuscript was written by Yukihiro Hama and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Conflict of interest
Y. Hama, T. Tsukamoto and E. Tate declare that they have no competing interests.
Ethical standards
Approval was obtained from the ethics committee of Edogawa Hospital. The procedures used in this study adhere to the tenets of the Declaration of Helsinki. Informed consent was obtained from all individual participants included in the study.
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Hama, Y., Tsukamoto, T. & Tate, E. High-dose planned adaptive helical tomotherapy for cutaneous angiosarcoma of the scalp. Strahlenther Onkol 200, 123–127 (2024). https://doi.org/10.1007/s00066-023-02093-7
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DOI: https://doi.org/10.1007/s00066-023-02093-7