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Assignment of human genes for β2 and β4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23

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Abstract

We have used human β2 and β4 cDNA probes to map the genes encoding two isoforms of the regulatory β subunit of voltage-activated Ca2+ channels, viz. CACNB2 (β2) and CACNB4 (β4), to human chromosomes 10p12 and 2q22-q23, respectively, by fluorescence in situ hybridization. The gene encoding the β2 protein, first described as a Lambert-Eaton myasthenic syndrome (LEMS) antigen in humans, is found close to a region that undergoes chromosome rearrangements in small cell lung cancer, which occurs in association with LEMS. CACNB2 (β2) and CACNB4 (β4) genes are members of the ion-channel gene superfamily and it should now be possible to examine their loci by linkage analysis of ion-channel-related disorders. To date, no such disease-related gene has been assigned to 10p12 and 2q22-q23.

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Authors and Affiliations

  1. CRBM–CNRS, BP 5051–1919, Route de Mende, F-34033 Montpellier cedex, France Tel.: +33-4-67-613355; Fax: +33-4-67-521559; e-mail: lory@xerxes.crbm.cnrs-mop.fr, , , , , , FR

    S. Taviaux, J. Nargeot & P. Lory

  2. SIBIA Neurosciences, Inc., 505 Coast Boulevard South, Suite 300, La Jolla, California 92037–4641, USA, , , , , , US

    M. E. Williams & M. M. Harpold

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  1. S. Taviaux
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  2. M. E. Williams
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  3. M. M. Harpold
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  4. J. Nargeot
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  5. P. Lory
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Received: 5 February 1997 / Accepted: 4 April 1997

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Taviaux, S., Williams, M., Harpold, M. et al. Assignment of human genes for β2 and β4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23. Hum Genet 100, 151–154 (1997). https://doi.org/10.1007/PL00008704

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  • DOI: https://doi.org/10.1007/PL00008704

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