References
Franks S. Polycystic ovary syndrome. N. Engl. J. Med. 333: 853, 1995.
Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr. Rev. 18: 774, 1997.
Zawadzky J.K., Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif A. et al. (Eds.), Current issues in endocrinology and metabolism: polycystic ovary syndrome. Blackwell, Boston, 1992, pp. 377.
Givens J.R., Andersen R.N., Wiser W.L., Donelson A.J., Coleman S.A. A testosterone-secreting, gonadotropin-responsive pure thecoma and polycystic ovarian disease. J. Clin. Endocrinol. Metab. 41: 845, 1975.
Dewailly D., Vantyghem-Haudiquet M.C., Sainsard C., et al. Clinical and biological phenotypes in late-onset 21-hydroxylase deficiency. J. Clin. Endocrinol. Metab. 63: 418, 1986.
Abbott D.H., Dumesic D.A., Eisner J.R., Kenmitz J.W., Goy R.W. The prenatally androgenized female rhesus monkey as a model for PCOS. In: Azziz R., Nestler J.E., Dewailly D. (Eds.), Androgen excess disorders in women. Lippincott-Raven, Philadelphia, 1997, p. 369.
Moghetti P., Tosi F., Castello R., et al. The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: evidence that androgens impair insulin action in women. J. Clin. Endocrinol. Metab. 81: 952, 1996.
Weil S.J., Vendola K., Zhou J., et al. Androgen receptor gene expression in the primate ovary: cellular localization, regulation, and functional correlations. J. Clin. Endocrinol. Metab. 83: 2479, 1998.
Billig H., Furuta I., Hsueh J.W. Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis. Endocrinology 133: 2204, 1993.
Lachelin G.C.L., Barnett M., Hopper B.R., Brink G., Yen S.S.C. Adrenal function in normal women and women with the polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 49: 892, 1979.
Yen S.S.C., Chaney C., Judd H.L. Functional aberrations of the hypothalamic-pituitary system in polycystic ovary syndrome. A consideration of the pathogenesis. In: James V.H., Serio M., Giusti G. (Eds.), The endocrine function of the human ovary. Academic Press, New York, 1976, p. 373.
Azziz R. Abnormalities of adrenocortical steroidogenesis in PCOS. In: Azziz R., Nestler J.E., Dewailly D. (Eds.), Androgen Excess Disorders in Women. Lippincott-Raven, Philadelphia, 1997, p. 403.
Moghetti P., Castello R., Negri C., et al. Insulin infusion amplifies 17α-hydroxycorticosteroid intermediates response to adrenocorticotropin in hyperandrogenic women: apparent relative impairment of 17,20-lyase activity. J. Clin. Endocrinol. Metab. 81: 881, 1996.
Rosenfield R.L. Evidence that idiopathic functional adrenal hyperandrogenism is caused by dysregulation of adrenal steroidogenesis and that hyperinsulinemia may be involved. J. Clin. Endocrinol. Metab. 81: 878, 1996.
Ditkoff E.C., Fruzzetti F., Chang L., Stanczyk F.Z., Lobo R.A. The impact of estrogen on adrenal androgen sensitivity and secretion in polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 80: 603, 1995.
Casson P.R., Kristiansen S.B., Umstot E., et al. Ovarian hyperstimulation augments adrenal dehydroepiandrosterone sulfate secretion. Fertil. Steril. 65: 950, 1996.
Barnes R.B., Rosenfield R.L., Burstein S., Ehrmann DA Pituitary-ovarian responses to nafarelin testing in the polycystic ovary syndrome. N. Engl. J. Med. 320: 559, 1989.
Ehrmann D.A., Barnes R.B., Rosenfield R.L. Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocr. Rev. 16: 322, 1995.
Dunaif A., Segal K.R., Futterweit W., Dobrjansky A. Profund peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 38: 1165, 1989.
Ovesen P., Moller J., Ingerslev H.J., et al. Normal basal and insulin-stimulated fuel metabolism in lean women with the polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 77: 1636, 1993.
Holte J., Bergh T., Berne C., Berglund L., Lithell H. Enhanced insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance. J. Clin. Endocrinol. Metab. 78: 1052, 1994.
Holte J., Bergh T., Berne C., Wide L., Lithell H. Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 80: 2586, 1995.
Bjorntorp P. Abdominal obesity and the development of noninsulin-dependent diabetes mellitus. Diabetes Metab. Rev. 4: 615, 1988.
Ferrannini E., Barrett E.J., Bevilacqua S., DeFronzo R.A. Effect of fatty acids on glucose production and utilization in man. J. Clin. Invest. 72: 1737, 1983.
Rodin A., Thakkar H., Yaylor N., Clayton R. Hyperandrogenism in polycystic ovary syndrome. Evidence of dysregulation of 11β-hydroxysteroid dehydrogenase. N. Engl. J. Med. 330: 460, 1994.
Lanzone A., Petraglia F., Fulghesu A.M., Ciampelli M., Caruso A., Mancuso S. Corticotropin-releasing hormone induces an exaggerated response of adrenocorticotropic hormone and cortisol in polycystic ovary syndrome. Fertil. Steril. 63: 1195, 1995.
Waterworth D.M., Bennet S.T., Gharani N., et al. Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome. Lancet 349: 986, 1997.
Barbieri R.L., Makris A., Randall R.W., Daniels G., Kristner R.W., Ryan K.J. Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J. Clin. Endocrinol. Metab. 62: 904, 1986.
Nestler J.E., Powers L.P., Matt D.W. A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 72: 83, 1991.
Velazquez E.M., Mendoza S., Hamer T., Sosa F., Glueck C.J. Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperan-drogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism 43: 647, 1994.
Nestler J.E., Jakubowicz D.J. Decreases in ovarian cytochrome P450c17α activity and serum free testosterone after reduction in insulin secretion in polycystic ovary syndrome. N. Engl. J. Med. 335: 617, 1996.
Dunaif A., Scott D., Finegood D., Quintana B., Whitcomb R. The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 81: 3299, 1996.
Ehrmann D.A., Schneider D.J., Sobel, et al. Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 82: 2108, 1997.
Nestler J.E., Jakubowicz D.J., Evans W.S., Pasquali R. Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N. Engl. J. Med. 338: 1876, 1998.
Dahlgren E., Janson P.O., Johansson S., Lapidus L., Oden A. Polycystic ovary syndrome and risk for myocardial infarction. Acta Obstet. Gynecol. Scand. 71: 599, 1992.
Birdsall M.A., Farquhar C.M., White H.D. Association between polycystic ovaries and extent of coronary artery disease in women having cardiac catheterization. Ann. Intern. Med. 126: 32, 1997.
Ibáñez L., Potau N., Virdis R., et al. Postpubertal outcome in girls diagnosed of premature pubarche during childhood: Increased frequency of functional ovarian hyperandrogenism. J. Clin. Endocrinol. Metab. 76: 1599, 1993.
Ibáñez L., Potau N., Zampolli M., Rique S., Saenger P., Carrascosa A. Hyperinsulinemia and decreased insulin-like growth factor-binding protein-1 are common features in prepubertal and pubertal girls with a history of premature pubarche. J. Clin. Endocrinol. Metab. 82: 2283, 1997.
Ibáñez L., Potau N., Francois I., de Zegher F. Precocious pubarche, hyperinsulinism and ovarian hyperandrogenism in girls: relation to reduced fetal growth. J. Clin. Endocrinol. Metab. 1998 (in press).
Donohue W.L., Uchida I. Leprechaunism: a euphemism for a rare familial disorder. J. Pediatr. 45: 505, 1954.
Barker D.J.P., Hales C.H.D., Osmond C., Clark P.M.S. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 36: 62, 1993.
Hofman P.L., Cutfield W.S., Robinson E.M., Bergman R.N., Menon R.K., Sperling M.A., Gluckman P.D. Insulin resistance in short children with intrauterine growth retardation. J. Clin. Endocrinol. Metab. 82: 402, 1997.
Taylor A.E., McCourt B., Anderson E.J., et al. Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovarian syndrome. J. Clin. Endocrinol. Metab. 82: 2248, 1997.
Rebar R., Judd H.L., Yen S.S.C., Rakoff J., Vandenberg G., Naftolin F. Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome. J. Clin. Invest. 57: 1320, 1976.
Pastor C.L., Griffin-Korf M.L., Aloi J.A., Evans W.S., Marshall J.C. Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone. J. Clin. Endocrinol. Metab. 83: 582, 1998.
Spinder T., Spijkstra J.J., Gooren L.J.G., Hompes P.G.A., van Kessel H. Effects of long-term testosterone administration on gonadotropin secretion in agonadal female to male transsexuals compared with hypogonadal and normal women. J. Clin. Endocrinol. Metab. 68: 200, 1989.
Sattar N., Hopkinson Z.O.C., Greer I.A. Insulin-sensitizing agents in polycystic ovary syndrome. Lancet 351: 305, 1998.
Adashi E.Y., Hsueh A.J.W., Yen S.C.C. Insulin enhancement of luteinizing hormone and follicle-stimulating hormone release by cultured pituitary cells. Endocrinology 108: 1441, 1981.
Toscano V., Adamo M.V., Caiola S., et al. Is hirsutism an evolving syndrome? J. Endocrinol. 97: 379, 1983.
Pasquali R., Antenucci D., Casimirri F., et al. Clinical and hormonal characteristics of obese amenorrheic hyperandrogenic women before and after weight loss. J. Clin. Endocrinol. Metab. 68: 173, 1989.
Prelevic G.M., Wurzburger M.I., Balint-Peric L., Nesic J.S. Inhibitory effect of sandostatin on luteinizing hormone and ovarian steroids in polycystic ovary syndrome. Lancet 336: 900, 1990.
Nestler J.E., Barlascini C.O., Matt D.W., et al. Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 68: 1027, 1989.
Moghetti P., Castello R., Negri C., et al. Metformin effects on endocrine features, menstrual pattern and insulin sensitivity in polycystic ovary syndrome: a double blind, placebo-controlled study. Proc. 79th Annual Meeting of the Endocrine Society, Minneapolis, June 1997 (abstract).
Inzucchi S.E., Maggs D.G., Spollet G.R., et al. Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus. N. Engl. J. Med. 338: 867, 1998.
De Ziegler D., Steingold K., Cedars M., et al. Recovery of hormone secretion after chronic GnRH-agonist administration in women with polycystic ovarian disease. J. Clin. Endocrinol. Metab. 68: 1111, 1989.
Christman G.M., Randolph J.F., Kelch R.P., Marshall J.C. Reduction of gonadotropin-releasing hormone pulse frequency is associated with subsequent selective follicle-stimulating hormone secretion in women with polycystic ovarian syndrome. J. Clin. Endocrinol. Metab. 72: 1278, 1991.
Godsland I.F., Walton C., Felton C., Proudler A., Patel A., Wynn V. Insulin resistance, secretion, and metabolism in users of oral contraceptives. J. Clin. Endocrinol. Metab. 74: 64, 1992.
Genazzani A.D., Petraglia F., Battaglia C., et al. A long-term treatment with gonadotropin-releasing hormone agonist plus a low-dose oral contraceptive improves the recovery of the ovulatory function in patients with polycystic ovary syndrome. Fertil. Steril. 67: 463, 1997.
De Leo V., Lanzetta D., D’Antona D., La Marca A., Morgante G. Hormonal effects of flutamide in young women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 83: 99, 1998.
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Moghetti, P., Castello, R. New routes in the polycystic ovary syndrome labyrinth: A way out?. J Endocrinol Invest 21, 648–655 (1998). https://doi.org/10.1007/BF03350793
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DOI: https://doi.org/10.1007/BF03350793